Product Name
Fibulin 5 (FBLN5), Monoclonal Antibody
Full Product Name
Fibulin 5 Monoclonal Antibody
Product Synonym Names
ADCL2; ARCL1A; ARMD3; Dance; Developmental arteries and neural crest EGF like protein; Developmental arteries and neural crest EGF-like protein; EVEC; Fbln5; FIBL 5; FIBL-5; Fibulin-5; FLJ90059; UP50; Urine p50 protein
Product Gene Name
anti-FBLN5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UBX5
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Caprylic acid/ammonium sulfate precipitation
Concentration
1mg/mL (lot specific)
Immunogen
Fusion protein of Fibulin 5
Buffer
PBS with 0.1% sodium azide, 50% glycerol, PH7.3
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-FBLN5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FBLN5 antibody
Fibulin-5, also known as EVEC and DANCE, is a extracellular matrix glycoprotein, secreted by various cell types such as vascular smooth muscle cells, fibroblasts and endothelial cells. Structurally, Fibulin-5 contains an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. FBLN5 mutations have been described in patients with age-related macular degeneration, as well as being involved in Charcot-Marie-Tooth neuropathies.
Product Categories/Family for anti-FBLN5 antibody
Cardiovascular; Signal transduction
Applications Tested/Suitable for anti-FBLN5 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)
Application Notes for anti-FBLN5 antibody
WB: 1:1500-1:5000
IF: 1:50-1:100
Western Blot (WB) of anti-FBLN5 antibody
Western Blot analysis of MCF-7 cells using Fibulin 5 Monoclonal Antibody at dilution of 1:3000
NCBI/Uniprot data below describe general gene information for FBLN5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006320.2
[Other Products]
NCBI GenBank Nucleotide #
NM_006329.3
[Other Products]
UniProt Primary Accession #
Q9UBX5
[Other Products]
UniProt Secondary Accession #
O75966; Q6IAL4; Q6UWA3[Other Products]
UniProt Related Accession #
Q9UBX5[Other Products]
Molecular Weight
Calculated: 50kDa
Observed: 50kDa
NCBI Official Full Name
fibulin-5
NCBI Official Synonym Full Names
fibulin 5
NCBI Official Symbol
FBLN5 [Similar Products]
NCBI Official Synonym Symbols
EVEC; UP50; ADCL2; ARMD3; DANCE; ARCL1A; FIBL-5; HNARMD
[Similar Products]
NCBI Protein Information
fibulin-5
UniProt Protein Name
Fibulin-5
UniProt Synonym Protein Names
Developmental arteries and neural crest EGF-like protein; Dance; Urine p50 protein; UP50
UniProt Gene Name
FBLN5 [Similar Products]
UniProt Synonym Gene Names
DANCE; FIBL-5; Dance; UP50 [Similar Products]
NCBI Summary for FBLN5
The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in ***** vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
UniProt Comments for FBLN5
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108).
Research Articles on FBLN5
1. Serum fibulin-5 concentration can be regarded as a biomarker for evaluating disease severity and predicting prognosis in intracerebral hemorrhage patients.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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