ATOX1, Polyclonal Antibody

ATX1; HAH1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total ATOX1 protein.

Antigen affinity purification.

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

1.8 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-ATOX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.

Total protein Ab

Immunohistochemistry (IHC)

Immunohistochemistry: 1:25-1:100

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue using at dilution 1/30.

Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/30.

7,402 Da

antioxidant 1 copper chaperone

copper transport protein ATOX1

Copper transport protein ATOX1

HAH1  [Similar Products]

ATOX1_HUMAN

This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]

ATOX1: Could bind and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. Belongs to the ATX1 family.

Protein type: Carrier

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: cytosol

Molecular Function: copper chaperone activity; copper ion binding; copper ion transmembrane transporter activity; copper-dependent protein binding; metallochaperone activity; protein binding

Biological Process: cellular copper ion homeostasis; copper ion transport; intracellular copper ion transport; response to oxidative stress; response to reactive oxygen species

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