Armadillo repeat protein deleted in velo-cardio-facial syndrome (ARVCF), ELISA

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

We suggest pre-experimenting with neat (undiluted) samples, 1:2 or 1:4 dilutions. Please avoid diluting your samples more than 1:10 as it would exceed the dilution limit set for this kit. If the expected concentration of the target is beyond the detection range of the kit, please contact our technical support team

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Small volumes of ARVCF elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS7203655 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Armadillo repeat protein deleted in velo-cardio-facial syndrome (ARVCF) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ARVCF. The ELISA analytical biochemical technique of the MBS7203655 kit is based on ARVCF antibody-ARVCF antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ARVCF antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ARVCF. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Signal Transduction

97,685 Da

armadillo repeat gene deleted in velocardiofacial syndrome

armadillo repeat protein deleted in velo-cardio-facial syndrome

Armadillo repeat protein deleted in velo-cardio-facial syndrome

ARVC_HUMAN

Armadillo Repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the catenin family. This family plays an important role in the formation of adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. The ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS), a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. The ARVCF gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein. [provided by RefSeq, Jun 2010]

ARVCF: Involved in protein-protein interactions at adherens junctions. Belongs to the beta-catenin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: nucleoplasm; cytoplasm; plasma membrane; intracellular; cell junction

Molecular Function: protein binding

Biological Process: cell-cell adhesion; multicellular organismal development; calcium-dependent cell-cell adhesion; cell adhesion

Disease: Velocardiofacial Syndrome

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