Product Name
Calsequestrin (Casq1), Monoclonal Antibody
Full Product Name
Calsequestrin
Product Synonym Names
Anti -Calsequestrin
Product Gene Name
anti-Casq1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 13; NC_005112.2 (88200506..88210418, complement). Location: 13q24
Species Reactivity
Canine, Mouse, Rabbit
Specificity
Recognizes mouse, rabbit and dog type I (slow) and type II (fast) calsequestrin. Detects a band of ~63kDa by Western blot.
Form/Format
Supplied as a liquid in PBS containing 0.05% sodium azide.
Immunogen
Purified rabbit skeletal muscle sarcoplasmic reticulum.
Preparation and Storage
-20 degree C
Other Notes
Small volumes of anti-Casq1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-Casq1 antibody
Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-Casq1 antibody
Western Blot (WB)
Application Notes for anti-Casq1 antibody
Western Blot (1:1'000)
NCBI/Uniprot data below describe general gene information for Casq1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001153066.1
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NCBI GenBank Nucleotide #
NM_001159594.1
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NCBI Official Full Name
calsequestrin 1
NCBI Official Synonym Full Names
calsequestrin 1 (fast-twitch, skeletal muscle)
NCBI Official Symbol
Casq1 [Similar Products]
NCBI Official Synonym Symbols
Casq1
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NCBI Protein Information
calsequestrin 1
Protein Family
Calsequestrin
UniProt Comments for Casq1
calsequestrin 1: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+). Belongs to the calsequestrin family.
Protein type: Calcium-binding; Mitochondrial
Cellular Component: I band; Golgi apparatus; sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; intracellular membrane-bound organelle; mitochondrion; sarcoplasmic reticulum; myofibril; T-tubule; mitochondrial matrix; cytoplasm; intracellular; sarcolemma
Molecular Function: calcium ion binding
Biological Process: protein polymerization; response to organic substance; regulation of skeletal muscle contraction via regulation of the release of sequestered calcium ion; endoplasmic reticulum organization and biogenesis; skeletal muscle development; regulation of sequestering of calcium ion; response to heat; response to denervation involved in regulation of muscle adaptation; sarcomere organization; response to muscle inactivity
Research Articles on Casq1
1. In EDL muscle, CSQ1 provides a large total pool of releasable Ca2+ in the SR whilst maintaining free [Ca2+] in the SR at sufficiently low levels that Ca2+ leakage through the high density of SERCA1 pumps does not metabolically compromise muscle function.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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