COX17, Polyclonal Antibody

Cytochrome c oxidase copper chaperone; COX17

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

>95%,Protein G purified

Liquid

Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of anti-COX17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

Western blot
All lanes: COX17 antibody at 3.5ug/ml+HepG-2 whole cell lysate
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 7 kDa
Observed band size: 7 kDa

Immunohistochemistry of paraffin-embedded human liver tissue using MBS7002538 at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using MBS7002538 at dilution of 1:100

Immunohistochemistry of paraffin-embedded human liver cancer using MBS7002538 at dilution of 1:100

6,915 Da

COX17 cytochrome c oxidase copper chaperone

cytochrome c oxidase copper chaperone

Cytochrome c oxidase copper chaperone

COX17_HUMAN

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]

COX17: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX. Belongs to the COX17 family.

Protein type: Energy Metabolism - oxidative phosphorylation; Mitochondrial

Chromosomal Location of Human Ortholog: 3q13.33

Cellular Component: cytoplasm; mitochondrial intermembrane space; mitochondrion

Molecular Function: copper chaperone activity; copper ion binding; protein binding

Biological Process: brain development; copper ion transport; generation of precursor metabolites and energy; heart development

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