Full Product Name
COX17 Antibody
Product Synonym Names
Cytochrome c oxidase copper chaperone; COX17
Product Gene Name
anti-COX17 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q14061
Species Reactivity
Human, Mouse, Rat
Specificity
The antibody detects endogenous levels of total COX17 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0 mg/ml (lot specific)
Immunogen Description
Synthesized peptide derived from N-terminal of human COX17.
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-COX17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-COX17 antibody
Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX By similarity.Amaravadi R., Hum. Genet. 99:329-333(1997).Punter F.A., Hum. Genet. 107:69-74(2000).The MGC Project Team, Genome Res. 14:2121-2127(2004).
Product Categories/Family for anti-COX17 antibody
Total protein Ab
Applications Tested/Suitable for anti-COX17 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-COX17 antibody
Western blotting: 1:500~1:3000
Immunohistochemistry: 1:50~1:100
Immunohistochemistry (IHC) of anti-COX17 antibody
Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue using COX17 antibody.
Western Blot (WB) of anti-COX17 antibody
Western blot analysis of extracts from HeLa cells, HepG2 cells, COLO cells and 293 cells, using COX17 antibody.
Western Blot (WB) of anti-COX17 antibody
Western blot analysis of extracts from 3T3 cells (Lane 2), using COX17 antiobdy. The lane on the left is treated with synthesized peptide.
NCBI/Uniprot data below describe general gene information for COX17. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005685.1
[Other Products]
NCBI GenBank Nucleotide #
NM_005694.1
[Other Products]
UniProt Primary Accession #
Q14061
[Other Products]
UniProt Secondary Accession #
Q3MHD6; B2R5D2; D3DN84[Other Products]
UniProt Related Accession #
Q14061[Other Products]
Molecular Weight
6,915 Da
NCBI Official Full Name
cytochrome c oxidase copper chaperone
NCBI Official Synonym Full Names
COX17 cytochrome c oxidase copper chaperone
NCBI Official Symbol
COX17 [Similar Products]
NCBI Protein Information
cytochrome c oxidase copper chaperone
UniProt Protein Name
Cytochrome c oxidase copper chaperone
Protein Family
Cytochrome c oxidase copper chaperone
UniProt Gene Name
COX17 [Similar Products]
UniProt Entry Name
COX17_HUMAN
NCBI Summary for COX17
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be involved in the recruitment of copper to mitochondria for incorporation into the COX apoenzyme. This protein shares 92% amino acid sequence identity with mouse and rat Cox17 proteins. This gene is no longer considered to be a candidate gene for COX deficiency. A pseudogene COX17P has been found on chromosome 13. [provided by RefSeq, Jul 2008]
UniProt Comments for COX17
COX17: Copper chaperone for cytochrome c oxidase (COX). Binds two copper ions and deliver them to the Cu(A) site of COX. Belongs to the COX17 family.
Protein type: Energy Metabolism - oxidative phosphorylation; Mitochondrial
Chromosomal Location of Human Ortholog: 3q13.33
Cellular Component: mitochondrion; cytoplasm; mitochondrial intermembrane space
Molecular Function: copper ion binding; copper chaperone activity
Biological Process: generation of precursor metabolites and energy; heart development; brain development; copper ion transport
Research Articles on COX17
1. CTR1 silencing increased the protein levels of copper chaperone ATOX1 and copper chaperone for superoxide dismutase 1 (CCS-1), but decreased copper chaperone for cytochrome c oxidase (COX17).
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
