Product Name
Arylsulfatase E (ARSE), Polyclonal Antibody
Full Product Name
Arylsulfatase E Polyclonal Antibody
Product Synonym Names
Arylsulfatase E; ASE
Product Gene Name
anti-ARSE antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51690
Purity/Purification
Affinity Purification
Concentration
1mg/mL (lot specific)
Immunogen
Synthesized peptide derived from the Internal region of human Arylsulfatase E
Buffer
PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol pH 7.4.
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-ARSE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARSE antibody
ARSE (Arylsulfatase E (Chondrodysplasia Punctata 1)) is a Protein Coding gene. Diseases associated with ARSE include Chondrodysplasia Punctata, X-Linked Recessive and Chondrodysplasia Punctata 1, X-Linked. Among its related pathways are Metabolism of proteins and Metabolism. GO annotations related to this gene include sulfuric ester hydrolase activity and arylsulfatase activity. An important paralog of this gene is ARSD.Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome.
Applications Tested/Suitable for anti-ARSE antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ARSE antibody
WB: 1:500-1:2000
ELISA: 1:10000
Western Blot (WB) of anti-ARSE antibody
Western Blot analysis of Mouse brain, Hela, SH-SY5Y using Arylsulfatase E Polyclonal Antibody at dilution of 1:1000.
NCBI/Uniprot data below describe general gene information for ARSE. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000038.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000047.2
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UniProt Primary Accession #
P51690
[Other Products]
UniProt Secondary Accession #
Q53FT2; Q53FU8[Other Products]
UniProt Related Accession #
P51690[Other Products]
Molecular Weight
Calculated Molecular Weight: 66kDa
Observed Molecular Weight: 65kDa
NCBI Official Full Name
arylsulfatase E isoform 2
NCBI Official Synonym Full Names
arylsulfatase E (chondrodysplasia punctata 1)
NCBI Official Symbol
ARSE [Similar Products]
NCBI Official Synonym Symbols
ASE; CDPX; CDPX1; CDPXR
[Similar Products]
NCBI Protein Information
arylsulfatase E
UniProt Protein Name
Arylsulfatase E
Protein Family
Arylsulfatase
UniProt Gene Name
ARSE [Similar Products]
UniProt Synonym Gene Names
ASE [Similar Products]
NCBI Summary for ARSE
Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013]
UniProt Comments for ARSE
ARSE: May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates. Defects in ARSE are the cause of chondrodysplasia punctata X-linked recessive type 1 (CDPX1). CDP is a clinically and genetically heterogeneous disorder characterized by punctiform calcification of the bones. CDPX1 is a congenital defect of bone and cartilage development characterized by aberrant bone mineralization, severe underdevelopment of nasal cartilage, and distal phalangeal hypoplasia. This disease can also be induced by inhibition with the drug warfarin. Belongs to the sulfatase family.
Protein type: EC 3.1.6.-; Hydrolase
Chromosomal Location of Human Ortholog: Xp22.33
Cellular Component: endoplasmic reticulum lumen; Golgi apparatus; Golgi stack
Molecular Function: arylsulfatase activity; metal ion binding
Biological Process: glycosphingolipid metabolic process; post-translational protein modification; skeletal system development
Disease: Chondrodysplasia Punctata 1, X-linked Recessive
Research Articles on ARSE
1. Data indicate that the neonatal detection test sensitivity obtained was 95% with a positive predictive value of 1 in the analyses for both the arylsulfatase E (ARSE) and melanoma antigen family H1 (MAGEH1) genes.
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