Full Product Name
4.1R (phospho Tyr660) Polyclonal Antibody
Product Gene Name
anti-4.1R antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11171
Other Notes
Small volumes of anti-4.1R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for 4.1R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001159477.1
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NCBI GenBank Nucleotide #
NM_001166005.1
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UniProt Primary Accession #
P11171
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UniProt Secondary Accession #
P11176; Q14245; Q5TB35; Q5VXN8; Q8IXV9; Q9Y578; Q9Y579; B1ALH8; B1ALH9; D3DPM9; D3DPN0[Other Products]
UniProt Related Accession #
P11171[Other Products]
Molecular Weight
81,235 Da
NCBI Official Full Name
protein 4.1 isoform 1
NCBI Official Synonym Full Names
erythrocyte membrane protein band 4.1
NCBI Official Symbol
EPB41 [Similar Products]
NCBI Official Synonym Symbols
HE; EL1; 4.1R
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NCBI Protein Information
protein 4.1
UniProt Protein Name
Protein 4.1
UniProt Synonym Protein Names
4.1R; Band 4.1; EPB4.1
UniProt Gene Name
EPB41 [Similar Products]
UniProt Synonym Gene Names
E41P; P4.1 [Similar Products]
NCBI Summary for 4.1R
The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
UniProt Comments for 4.1R
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127).
Research Articles on 4.1R
1. 6 Single Nucleotide Polymorphisms within the EPB41 gene are significantly associated with Mandibular Prognathism (rs2762686, rs2788888, rs4654388, rs502393, rs11581096, and rs488113). The G-allele of SNP, assigned as rs4654388, showed the strongest link with an increased risk of Mandibular Prognathism in the Chinese population.
Precautions
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Disclaimer
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