THAP domain containing, apoptosis associated protein 1, ELISA Kit

Mouse THAP domain-containing protein 1 (THAP1) ELISA kit; DYT6; FLJ10477; MGC33014; 4833431A01Rik; THAP domain protein 1; nuclear proapoptotic factor; THAP domain containing; apoptosis associated protein 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of THAP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9339416 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the THAP domain containing, apoptosis associated protein 1 (THAP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing THAP1. The ELISA analytical biochemical technique of the MBS9339416 kit is based on THAP1 antibody-THAP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect THAP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, THAP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

24,611 Da

THAP domain containing, apoptosis associated protein 1

THAP domain-containing protein 1

THAP domain-containing protein 1

THAP1_MOUSE

THAP1: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis. Defects in THAP1 are the cause of dystonia type 6 (DYT6). DYT6 is a primary torsion dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Dystonia type 6 is characterized by onset in early *****hood, cranial or cervical involvement in about half of the cases, and frequent progression to involve multiple body regions. Belongs to the THAP1 family.

Protein type: DNA-binding; Transcription factor; Cell cycle regulation

Cellular Component: nucleus

Molecular Function: nucleic acid binding; DNA binding; zinc ion binding; sequence-specific DNA binding; metal ion binding

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; endothelial cell proliferation; regulation of mitotic cell cycle; cell cycle

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