Full Product Name
FOXE3 Antibody, HRP conjugated
Product Synonym Names
Forkhead box protein E3; Forkhead-related protein FKHL12; Forkhead-related transcription factor 8; FREAC-8; FOXE3; FKHL12; FREAC8
Product Gene Name
anti-FOXE3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q13461
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Forkhead box protein E3 protein (4-74AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-FOXE3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FOXE3 antibody
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (By similarity). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (By similarity). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149).
Product Categories/Family for anti-FOXE3 antibody
Epigenetics and Nuclear Signaling
Applications Tested/Suitable for anti-FOXE3 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for FOXE3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036318.1
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NCBI GenBank Nucleotide #
NM_012186.2
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UniProt Primary Accession #
Q13461
[Other Products]
UniProt Secondary Accession #
Q5SVY9; Q9NQV9[Other Products]
UniProt Related Accession #
Q13461[Other Products]
Molecular Weight
33,234 Da
NCBI Official Full Name
forkhead box protein E3
NCBI Official Synonym Full Names
forkhead box E3
NCBI Official Symbol
FOXE3 [Similar Products]
NCBI Official Synonym Symbols
AAT11; ASGD2; FKHL12; FREAC8; CTRCT34
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NCBI Protein Information
forkhead box protein E3
UniProt Protein Name
Forkhead box protein E3
UniProt Synonym Protein Names
Forkhead-related protein FKHL12; Forkhead-related transcription factor 8; FREAC-8
Protein Family
Forkhead box protein
UniProt Gene Name
FOXE3 [Similar Products]
UniProt Synonym Gene Names
FKHL12; FREAC8; FREAC-8 [Similar Products]
NCBI Summary for FOXE3
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. The protein encoded functions as a lens-specific transcription factor and plays an important role in vertebrate lens formation. Mutations in this gene are associated with anterior segment mesenchymal dysgenesis and congenital primary aphakia. [provided by RefSeq, Dec 2009]
UniProt Comments for FOXE3
Transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis and cell cycle (PubMed:22527307, PubMed:25504734). During lens development, controls the ratio of the lens fiber cells to the cells of the anterior lens epithelium by regulating the rate of proliferation and differentiation (). Controls lens vesicle closure and subsequent separation of the lens vesicle from ectoderm (). Controls the expression of DNAJB1 in a pathway that is crucial for the development of the anterior segment of the eye (PubMed:27218149).
Research Articles on FOXE3
1. C, p.Gly158Arg) was identified being homozygous in the three affected and heterozygous in the two unaffected, which was confirmed by Sanger sequencing.">Only one novel missense mutation in exon 1 of FOXE3 (Chr1:47,882,459, c.472G>C, p.Gly158Arg) was identified being homozygous in the three affected and heterozygous in the two unaffected, which was confirmed by Sanger sequencing.
Precautions
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Disclaimer
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