Product Name
Active regulator of SIRT1 protein (RPS19), Recombinant Protein
Full Product Name
Recombinant human Active regulator of SIRT1 protein
Product Gene Name
RPS19 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MPGVTVKDVN QQEFVRALAA FLKKSGKLKV PEWVDTVKLA KHKELAPYDE NWFYTRAAST ARHLYLRGGA GVGSMTKIYG GRQRNGVMPS HFSRGSKSVA RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA ANKKH
Chromosome Location
Chromosome: 19; NC_000019.9 (42363988..42375484). Location: 19q13.2
3D Structure
ModBase 3D Structure for P39019
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Preparation and Storage
Store at -20 degree C. For extended storage, conserve at -20 or -80 degree C.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of RPS19 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
SDS-PAGE of RPS19 recombinant protein
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for RPS19. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001013.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001022.3
[Other Products]
UniProt Primary Accession #
P39019
[Other Products]
UniProt Related Accession #
P39019[Other Products]
Molecular Weight
43 KD[Similar Products]
NCBI Official Full Name
Homo sapiens ribosomal protein S19 (RPS19), mRNA
NCBI Official Synonym Full Names
ribosomal protein S19
NCBI Official Symbol
RPS19 [Similar Products]
NCBI Official Synonym Symbols
DBA; S19; DBA1
[Similar Products]
NCBI Protein Information
40S ribosomal protein S19
UniProt Protein Name
40S ribosomal protein S19
Protein Family
Ribosomal protein
UniProt Gene Name
RPS19 [Similar Products]
UniProt Entry Name
RS19_HUMAN
NCBI Summary for RPS19
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
UniProt Comments for RPS19
Function: Required for pre-rRNA processing and maturation of 40S ribosomal subunits. Ref.8
Subunit structure: Interacts with RPS19BP1
By similarity.
Subcellular location: Nucleus. Note: Located more specifically in the nucleoli. Ref.9 Ref.15
Tissue specificity: Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.
Involvement in disease: Defects in RPS19 are the cause of Diamond-Blackfan anemia type 1 (DBA1) [
MIM:105650]. DBA1 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Ref.2 Ref.9 Ref.13 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18
Sequence similarities: Belongs to the ribosomal protein S19e family.
Research Articles on RPS19
1. Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A deletion, 3 with RPS17 deletions, and 1 with an RPS19 deletion.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
