CYSLTR1 / CYSLT1, Polyclonal Antibody

Anti-CYSLTR1 / CYSLT1 Antibody (Extracellular Domain) IHC-plus; CYSLTR1; Cys-LT1 receptor; CysLT(1); Cys-leukotriene-1 receptor; CYSLT1; CYSLT1R; CYSLTR; HG55; LTD4 receptor; HMTMF81; Cysteinyl lt1 receptor; Human CYSLTR1; CYSLT1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Human CYSLTR1 / CYSLT1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NMU (45%).

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml (lot specific)

Long term: -70 degree C; Short term: +4 degree C

Small volumes of anti-CYSLTR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Cysteinyl leukotriene receptor 1, a Chemoattractant Receptor, is detected in spleen, peripheral blood leukocytes, and lung smooth muscle (Lynch et al., 1999). It binds cysteinyl leukotrienes, which are neutrophil chemoattractants with potent proinflammatory action. Leukotrienes mediate many features of bronchial asthma such as edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Selective CysLT1 antagonists are used to treat asthma.

Subfamily:-Chemoattractant">Family: GPCR
Subfamily: Chemoattractant

Immunohistochemistry (IHC - Paraffin)

IHC-P (6 - 14 ug/ml)

Anti-CYSLTR1 / CYSLT1 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CYSLTR1 / CYSLT1 antibody IHC of human nasal mucosa, allergic rhinitis, eosinophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

38,541 Da

cysteinyl leukotriene receptor 1

cysteinyl leukotriene receptor 1; LTD4 receptor; G-protein coupled receptor HG55; cysteinyl leukotriene D4 receptor

Cysteinyl leukotriene receptor 1

CYSLT1; CysLTR1; LTD4 receptor  [Similar Products]

CLTR1_HUMAN

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for cysteinyl leukotrienes, and is involved in mediating bronchoconstriction via activation of a phosphatidylinositol-calcium second messenger system. Activation of the encoded receptor results in contraction and proliferation of bronchial smooth muscle cells, eosinophil migration, and damage to the mucus layer in the lung. Upregulation of this gene is associated with asthma and dysregulation may also be implicated in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

CYSLTR1: Receptor for cysteinyl leukotrienes mediating bronchoconstriction of individuals with and without asthma. Stimulation by LTD4 results in the contraction and proliferation of smooth muscle, edema, eosinophil migration and damage to the mucus layer in the lung. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTD4 >> LTE4 = LTC4 >> LTB4. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq13.2-q21.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; leukotriene receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; elevation of cytosolic calcium ion concentration; calcium ion transport; positive regulation of vasoconstriction; defense response; respiratory gaseous exchange; chemotaxis; inflammatory response

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