tubby like protein 1, ELISA Kit

Mouse Tubby-related protein 1 (TULP1) ELISA kit; RP14; TUBL1; Tubby related protein 1 (Tubby-like protein 1) ; tubby like protein 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of TULP1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9335774 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the tubby like protein 1 (TULP1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TULP1. The ELISA analytical biochemical technique of the MBS9335774 kit is based on TULP1 antibody-TULP1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TULP1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TULP1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

60,336 Da

tubby like protein 1

tubby-related protein 1; tubby-like protein 1; tubby like protein 1 like

Tubby-related protein 1

TULP1_MOUSE

TULP1: Required for normal development of photoreceptor synapses. Required for normal photoreceptor function and for long- term survival of photoreceptor cells. Interacts with cytoskeleton proteins and may play a role in protein transport in photoreceptor cells. Binds lipids, especially phosphatidylinositol 3-phosphate, phosphatidylinositol 4- phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-bisphosphate, phosphatidylserine and phosphatidic acid (in vitro). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages. Defects in TULP1 are the cause of retinitis pigmentosa type 14 (RP14). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP14 inheritance is autosomal recessive. Defects in TULP1 are the cause of Leber congenital amaurosis type 15 (LCA15). LCA15 is a severe dystrophy of the retina, typically becoming evident in the first years of life. Visual function is usually poor and often accompanied by nystagmus, sluggish or near-absent pupillary responses, photophobia, high hyperopia and keratoconus. Belongs to the TUB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal

Cellular Component: photoreceptor outer segment; photoreceptor inner segment; cell projection; membrane; cytoplasm; plasma membrane; extracellular region; synapse; nerve terminal; cell junction; cytosol

Molecular Function: actin filament binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding

Biological Process: vesicle-mediated transport; retinal homeostasis; eye photoreceptor cell development; visual perception; retina development in camera-type eye; positive regulation of phagocytosis; response to stimulus; photoreceptor cell maintenance; dendrite development; detection of light stimulus involved in visual perception; phagocytosis, recognition; phagocytosis

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