Full Product Name
ARPC2 (Actin Related Protein 2/3 Complex Subunit 2 34kD, ARC34, PRO2446, p34-Arc, PNAS-139, ARP2/3 Protein Compex Subunit 34)
Product Synonym Names
Anti -ARPC2 (Actin Related Protein 2/3 Complex Subunit 2 34kD, ARC34, PRO2446, p34-Arc, PNAS-139, ARP2/3 Protein Compex Subunit 34)
Product Gene Name
anti-ARPC2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
MILLEVNNRI IEETLALKFE NAAAGNKPEA VEVTFADFDG VLYHISNPNG DKTKVMVSIS LKFYKELQAH GADELLKRVY GSFLVNPESG YNVSLLYDLE NLPASKDSIV HQAGMLKRNC FASVFEKYFQ FQEEGKEGEN RAVIHYRDDE TMYVESKKDR VTVVFSTVFK DDDDVVIGKV FMQEFKEGRR ASHTAPQVLF SHREPPLELK DTDAAVGDNI GYITFVLFPR HTNASARDNT INLIHTFRDY LHYHIKCSKA YIHTRMRAKT SDFLKVLNRA RPDAEKKEMK TITGKTFSSR
Chromosome Location
Chromosome: 2; NC_000002.11 (219081817..219119071). Location: 2q36.1
3D Structure
ModBase 3D Structure for O15144
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes human ARPC2. Species Crossreactivity: mouse and rat.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Immunogen
Full length recombinant protein corresponding to aa1-300 from ARPC2 (AAH00590) with GST tag. MW of the GST tag alone is 26kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-ARPC2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARPC2 antibody
The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.
Product Categories/Family for anti-ARPC2 antibody
Antibodies; Abs to Actin Related Proteins
Applications Tested/Suitable for anti-ARPC2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ARPC2 antibody
Suitable for use in ELISA and Western Blot.
NCBI/Uniprot data below describe general gene information for ARPC2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_690601.1
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NCBI GenBank Nucleotide #
NM_152862.2
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UniProt Primary Accession #
O15144
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UniProt Secondary Accession #
Q92801; Q9P1D4[Other Products]
UniProt Related Accession #
O15144[Other Products]
Molecular Weight
34,333 Da[Similar Products]
NCBI Official Full Name
actin-related protein 2/3 complex subunit 2
NCBI Official Synonym Full Names
actin related protein 2/3 complex, subunit 2, 34kDa
NCBI Official Symbol
ARPC2 [Similar Products]
NCBI Official Synonym Symbols
ARC34; PRO2446; p34-Arc; PNAS-139
[Similar Products]
NCBI Protein Information
actin-related protein 2/3 complex subunit 2; arp2/3 complex 34 kDa subunit; ARP2/3 protein complex subunit 34
UniProt Protein Name
Actin-related protein 2/3 complex subunit 2
UniProt Synonym Protein Names
Arp2/3 complex 34 kDa subunit
UniProt Gene Name
ARPC2 [Similar Products]
UniProt Synonym Gene Names
ARC34; p34-ARC [Similar Products]
UniProt Entry Name
ARPC2_HUMAN
NCBI Summary for ARPC2
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for ARPC2
ARPC2: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament. Belongs to the ARPC2 family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Actin-binding
Chromosomal Location of Human Ortholog: 2q36.1
Cellular Component: Golgi apparatus; neuron projection; Arp2/3 protein complex; focal adhesion; cytoplasm; leading edge; plasma membrane; synapse; cytosol; endosome; actin cytoskeleton
Molecular Function: actin filament binding; protein binding; structural constituent of cytoskeleton; kinesin binding
Biological Process: axon guidance; ephrin receptor signaling pathway; innate immune response; cell motility
Research Articles on ARPC2
1. The Arp2/3 complex is recruited to invading Rickettsia parkeri and is required for efficient invasion.
Precautions
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Disclaimer
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