Full Product Name
Mouse Monoclonal Antibody to THAP1
Product Synonym Names
DYT6
Product Gene Name
anti-THAP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NVV9
Immunogen
Full length(1-213)
Other Notes
Small volumes of anti-THAP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-THAP1 antibody
Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-THAP1 antibody
Western blot using Recombinant protein
Western blot using Transfection expressed protein
NCBI/Uniprot data below describe general gene information for THAP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_945354.1
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NCBI GenBank Nucleotide #
NM_199003.1
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UniProt Primary Accession #
Q9NVV9
[Other Products]
UniProt Secondary Accession #
Q53FQ1; Q6IA99; A6NCB6; D3DSY5; H9KV49[Other Products]
UniProt Related Accession #
Q9NVV9[Other Products]
NCBI Official Full Name
THAP domain-containing protein 1 isoform 2
NCBI Official Synonym Full Names
THAP domain containing 1
NCBI Official Symbol
THAP1 [Similar Products]
NCBI Official Synonym Symbols
DYT6
[Similar Products]
NCBI Protein Information
THAP domain-containing protein 1
UniProt Protein Name
THAP domain-containing protein 1
Protein Family
THAP domain-containing protein
UniProt Gene Name
THAP1 [Similar Products]
NCBI Summary for THAP1
The protein encoded by this gene contains a THAP domain, a conserved DNA-binding domain. This protein colocalizes with the apoptosis response protein PAWR/PAR-4 in promyelocytic leukemia (PML) nuclear bodies, and functions as a proapoptotic factor that links PAWR to PML nuclear bodies. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
UniProt Comments for THAP1
DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Research Articles on THAP1
1. The region of amino acids 139-185 is involved in formation of THAP1 homodimers.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
