Full Product Name
Rabbit Anti Human KCNQ1 PolyClonal Antibody
Product Synonym Names
KCNQ1; ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; KVLQT1; Kv1.9; Kv7.1; LQT; LQT1; RWS; SQT2; WRS
Product Gene Name
anti-KCNQ1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P97414
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity Purification
Relevance
KCNQ1 is a protein for a voltage-gated potassium channel required for the repolarization phase of the cardiac action potential. The gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3.
Storage Buffer
Store at -20 degree C or -80 degree C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-KCNQ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KCNQ1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for KCNQ1. It may not necessarily be applicable to this product.
NCBI Accession #
CAA05246.1
[Other Products]
UniProt Primary Accession #
P97414
[Other Products]
UniProt Secondary Accession #
O88702; Q3U4H1; Q7TNZ1; Q7TPL7; Q80VR7[Other Products]
UniProt Related Accession #
P97414[Other Products]
Molecular Weight
62,640 Da
NCBI Official Full Name
Kcnq1, partial
NCBI Official Synonym Full Names
potassium voltage-gated channel, subfamily Q, member 1
NCBI Official Symbol
Kcnq1 [Similar Products]
NCBI Official Synonym Symbols
Kcna9; KVLQT1; AW559127
[Similar Products]
NCBI Protein Information
potassium voltage-gated channel subfamily KQT member 1; KQT-like 1; voltage-gated potassium channel subunit Kv7.1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1
UniProt Protein Name
Potassium voltage-gated channel subfamily KQT member 1
UniProt Synonym Protein Names
IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1; Voltage-gated potassium channel subunit Kv7.1
Protein Family
KCNQ1 downstream neighbor protein
UniProt Gene Name
Kcnq1 [Similar Products]
UniProt Synonym Gene Names
Kcna9; Kvlqt1 [Similar Products]
UniProt Entry Name
KCNQ1_MOUSE
UniProt Comments for KCNQ1
Kv7.1: a voltage-gated potassium channel protein required for the repolarization phase of the cardiac action potential. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea. Abundantly expressed in heart, pancreas, prostate, kidney, small intestine and peripheral blood leukocytes. Less abundant in placenta, lung, spleen, colon, thymus, testis and ovaries. Three alternatively spliced isoforms have been described.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium
Cellular Component: voltage-gated potassium channel complex; zymogen granule membrane; cytoplasmic vesicle membrane; membrane; basolateral plasma membrane; lysosome; integral to plasma membrane; early endosome; late endosome; plasma membrane; integral to membrane; cytoplasmic vesicle; sarcolemma
Molecular Function: calmodulin binding; voltage-gated potassium channel activity; protein homodimerization activity; potassium channel activity; delayed rectifier potassium channel activity; outward rectifier potassium channel activity; ion channel activity; voltage-gated ion channel activity; protein phosphatase 1 binding
Biological Process: regulation of membrane potential; genetic imprinting; transport; positive regulation of heart rate; ion transport; gene silencing; transmembrane transport; potassium ion transport; cardiac muscle contraction; negative regulation of insulin secretion
Research Articles on KCNQ1
1. KCNQ1, KCNE2, and SMIT1 form reciprocally regulating complexes that affect neuronal excitability.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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