LKB1, Polyclonal Antibody

LKB1; PJS; Serine/threonine-protein kinase STK11; Liver kinase B1; LKB1; hLKB1; Renal carcinoma antigen NY-REN-19

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Recognizes endogenous levels of LKB1 (pT189) protein.

The antibody was purified by immunogen affinity chromatography.

Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.

Shipped and store at 4 degree C for one year. Do not freeze.

Small volumes of anti-STK11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Rabbit polyclonal antibody to LKB1 (pT189)

Western Blot (WB)

Western Blot: (1/500 - 1/1000)

Western blot analysis of LKB1 (pT189) expression in A431 (A), Jurkat (B), NIH3T3 (C) whole cell lysates.

45,387 Da

serine/threonine kinase 11

serine/threonine-protein kinase STK11

Serine/threonine-protein kinase STK11

LKB1; PJS; LKB1; hLKB1  [Similar Products]

STK11_HUMAN

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.

Protein type: Autophagy; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor; EC 2.7.11.1; Protein kinase, CAMK; Kinase, protein; CAMK group; CAMKL family; LKB subfamily

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleus

Molecular Function: ATP binding; LRR domain binding; magnesium ion binding; p53 binding; protein binding; protein kinase activator activity; protein serine/threonine kinase activity

Biological Process: activation of protein kinase activity; anoikis; autophagy; axonogenesis; cell cycle arrest; energy reserve metabolic process; establishment of cell polarity; glucose homeostasis; Golgi localization; insulin receptor signaling pathway; negative regulation of cell growth; negative regulation of cell proliferation; positive regulation of autophagy; positive regulation of axonogenesis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; positive thymic T cell selection; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell growth; regulation of dendrite morphogenesis; regulation of fatty acid biosynthetic process; regulation of protein kinase B signaling cascade; regulation of Wnt receptor signaling pathway; response to DNA damage stimulus; response to ionizing radiation; spermatid development; T cell receptor signaling pathway; tissue homeostasis; vasculature development; Wnt receptor signaling pathway through beta-catenin

Disease: Pancreatic Cancer; Peutz-jeghers Syndrome; Testicular Germ Cell Tumor

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