BCS1L, Polyclonal Antibody

BCS 1; BCS 1L; BCS; BCS1 (yeast homolog) like; BCS1; BCS1 like (S. cerevisiae); BCS1 like; BCS1 like protein; Bjornstad syndrome (pili torti and deafness); BJS; FLNMS; GRACILE; h BCS; H BCS1; Hs.6719; Mitochondrial chaperone BCS1; Mitochondrial complex III assembly; PTD

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

BCS1L antibody detects endogenous levels of BCS1L.

The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.

Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

1mg/ml (lot specific)

Store at -20 degree C. Stable for 12 months from date of receipt.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.

Small volumes of anti-BCS1L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Function: Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex.
Subunit Structure: Interacts with LETM1.
Similarity: Belongs to the AAA ATPase family. BCS1 subfamily.

Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:2000
IHC: 1:50-1:200

Western blot analysis of extracts from HepG2, using BCS1L antibody. Lane 1 was treated with the blocking peptide.

MBS9603417 at 1/100 staining Human breast cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.

Western blot analysis of extracts of HEK-293 cells, using BCS1L antibody.

Observed: 50-55 kDa
Predicted: 48 kDa

BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone

mitochondrial chaperone BCS1

Mitochondrial chaperone BCS1

BCS1; h-BCS1  [Similar Products]

This gene encodes a homolog of the S. cerevisiae bcs1 protein which is involved in the assembly of complex III of the mitochondrial respiratory chain. The encoded protein does not contain a mitochondrial targeting sequence but experimental studies confirm that it is imported into mitochondria. Mutations in this gene are associated with mitochondrial complex III deficiency and the GRACILE syndrome. Several alternatively spliced transcripts encoding two different isoforms have been described. [provided by RefSeq, Jan 2016]

Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex.

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