Microphthalmia Associated Transcription Factor (MITF), Recombinant Protein

WS2A; MI; bHLHe32; Homolog Of Mouse Microphthalmia; Class E basic helix-loop-helix protein 32

For Research Use Only. Not for use in diagnostic procedures.

E Coli

> 95%

Freeze-dried powder

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of MITF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Signal transduction

Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)

Predicted Molecular Weight: 61.9kDa
Accurate Molecular Weight: 62kDa

melanogenesis associated transcription factor

microphthalmia-associated transcription factor

Microphthalmia-associated transcription factor

BHLHE32; bHLHe32  [Similar Products]

The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome. [provided by RefSeq, Aug 2017]

MITF: a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. Plays a critical role in the differentiation of various cell types including neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Two isoforms are known: the M-isoform is expressed exclusively in melanocytes, while the A-isoform has a much broader range of expression. Mutations in MITF can lead to Waardenburg syndrome. Ten alternatively spliced isoforms have been described.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 3p13

Cellular Component: nucleoplasm; nucleus; protein complex

Molecular Function: chromatin binding; protein binding; protein dimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

Biological Process: bone remodeling; camera-type eye development; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; cell fate commitment; melanocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; osteoclast differentiation; positive regulation of DNA-templated transcription, initiation; positive regulation of gene expression; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein complex assembly; protein sumoylation; regulation of cell proliferation; regulation of osteoclast differentiation; regulation of RNA biosynthetic process; regulation of transcription, DNA-templated; transcription from RNA polymerase II promoter

Disease: Albinism, Ocular, With Sensorineural Deafness; Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, And Deafness; Melanoma, Cutaneous Malignant, Susceptibility To, 8; Tietz Syndrome; Waardenburg Syndrome, Type 2a

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