Product Name
Nephrin (Nphs1), Recombinant Protein
Popular Item
Full Product Name
Recombinant Rat Nephrin (Nphs1) , partial
Product Gene Name
Nphs1 recombinant protein
[Similar Products]
Product Synonym Gene Name
Nphs1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9R044
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Nphs1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
SDS-PAGE of Nphs1 recombinant protein
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
NCBI/Uniprot data below describe general gene information for Nphs1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_072150.1
[Other Products]
NCBI GenBank Nucleotide #
NM_022628.1
[Other Products]
UniProt Primary Accession #
Q9R044
[Other Products]
UniProt Secondary Accession #
Q9JIX2; Q9QXX7[Other Products]
UniProt Related Accession #
Q9R044[Other Products]
Molecular Weight
126,646 Da
NCBI Official Full Name
nephrin
NCBI Official Synonym Full Names
NPHS1 nephrin
NCBI Official Symbol
Nphs1 [Similar Products]
NCBI Protein Information
nephrin
UniProt Protein Name
Nephrin
UniProt Synonym Protein Names
Renal glomerulus-specific cell adhesion receptor
UniProt Gene Name
Nphs1 [Similar Products]
UniProt Synonym Gene Names
Nphn [Similar Products]
NCBI Summary for Nphs1
renal protein localized specifically to glomerular capillary walls; may contribute to the development of proteinuria in renal disease [RGD, Feb 2006]
UniProt Comments for Nphs1
Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.
Research Articles on Nphs1
1. Data show that metformin provides some protection against podocyte damage in diabetic rats, which may be related, in part, to its effect in reducing urinary nephrin (Nphs1) excretion as well as improving podocyte nephrin expression.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
