LKB1, Polyclonal Antibody

Serine/threonine kinase 11; Serine/threonine protein kinase 11; Renal carcinoma antigen NY-REN-19; polarization-related protein LKB1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Affinity purified

100 ug (0.5 mg/ml) affinity purified rabbit anti-LKB1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Appearance: Colorless liquid

0.5 mg/ml (lot specific)

At -20 degree C
Shelf Life: 12 months

Small volumes of anti-LKB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Background: LKB1 is a tumor suppressor that belongs to the serine/threonine kinase family. Mutation in LKB1 is link to Peutz Jeghers syndrome (PJS), a disorder characterized by the growth of polyps in the gastrointestinal tract. LKB1 regulate AMPK signaling pathway and may also play a role in chromatin remodeling, cell cycle arrest and cell polarity

Western Blot (WB)

The antibody can be used for Western blotting (0.5-4 ug/ml).

46,494 Da

serine/threonine kinase 11

serine/threonine-protein kinase STK11

Serine/threonine-protein kinase STK11

LKB1; mLKB1  [Similar Products]

STK11_MOUSE

This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]

LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.

Protein type: Tumor suppressor; Autophagy; Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; LKB subfamily

Cellular Component: protein complex; membrane; mitochondrion; cytoplasm; nucleus; cytosol

Molecular Function: p53 binding; metal ion binding; magnesium ion binding; nucleotide binding; LRR domain binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; protein complex binding; kinase activity; protein kinase activator activity; ATP binding

Biological Process: Golgi localization; protein heterooligomerization; apoptosis; regulation of dendrite morphogenesis; protein amino acid autophosphorylation; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; response to lipid; protein amino acid phosphorylation; T cell receptor signaling pathway; anoikis; negative regulation of cell proliferation; positive regulation of gluconeogenesis; vasculature development; tissue homeostasis; regulation of cell growth; cell cycle arrest; cell differentiation; positive thymic T cell selection; regulation of Wnt receptor signaling pathway; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein kinase B signaling cascade; cell cycle; positive regulation of peptidyl-tyrosine phosphorylation; axonogenesis; establishment of cell polarity; positive regulation of protein kinase activity; activation of protein kinase activity; autophagy; spermatogenesis; positive regulation of axonogenesis; response to ionizing radiation; negative regulation of cell growth; phosphorylation; response to DNA damage stimulus; spermatid development

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