Ketohexokinase (KHK), Recombinant Protein

Ketohexokinase; EC=2.7.1.3; Hepatic fructokinase

For Research Use Only. Not for use in diagnostic procedures.

E Coli or Yeast or Baculovirus or Mammalian Cell

>=90% (lot specific)

Liquid containing glycerol

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterile filter available upon request.

Low endotoxin available upon request.

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Small volumes of KHK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

KHK

Signal Transduction

(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)

32,523 Da

ketohexokinase (fructokinase)

ketohexokinase; hepatic fructokinase

Ketohexokinase

KHK_HUMAN

This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

KHK iso2: Defects in KHK are the cause of fructosuria (FRUCT). Benign defect of intermediary metabolism. Belongs to the carbohydrate kinase PfkB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.3; Transferase

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: ketohexokinase activity; ATP binding

Biological Process: carbohydrate metabolic process; carbohydrate phosphorylation; pathogenesis; fructose catabolic process

Disease: Fructosuria, Essential

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