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Alkaline phosphatase, Protein

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产品名称: Alkaline phosphatase, Protein
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简单介绍

Alkaline phosphatase, Protein


Alkaline phosphatase, Protein  的详细介绍
Product Name

Alkaline phosphatase (ALPL), Protein

Full Product Name

Alkaline phosphatase, tissue-nonspecific isozyme

Product Synonym Names
Alkaline phosphatase liver/bone/kidney isozyme
Product Gene Name

ALPL protein

[Similar Products]
Matching Pairs
Antibody: ALPL (MBS2894760)
Antigen: Alkaline phosphatase (MBS2888960)
Matching Pairs
Antibody: ALPL (MBS2894761)
Antigen: Alkaline phosphatase (MBS2888960)
Matching Pairs
Antibody: ALPL (MBS2894762)
Antigen: Alkaline phosphatase (MBS2888960)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
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Sequence Positions
80-205aa
OMIM
146300
3D Structure
ModBase 3D Structure for P05186
Host
E Coli
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid
Tags
His
Endotoxin Level
<0.10 EU per 1 mug of the protein by the LAL method
Storage Buffer
50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole,10%glycerol(PH8.0)
Preparation and Storage
Store at -20 degree C.
Avoid repeated freezing and thawing.
Other Notes
Small volumes of ALPL protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Applications Tested/Suitable for ALPL protein
ELISA (EIA), Western Blot (WB), Affinity Purification (AP), Protein Array
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NCBI/Uniprot data below describe general gene information for ALPL. It may not necessarily be applicable to this product.
NCBI GI #
116734717
NCBI GeneID
249
NCBI Accession #
NP_000469.3 [Other Products]
NCBI GenBank Nucleotide #
NM_000478.5 [Other Products]
UniProt Primary Accession #
P05186 [Other Products]
UniProt Secondary Accession #
O75090; Q2TAI7; Q59EJ7; Q5BKZ5; Q5VTG5; Q6NZI8; Q8WU32; A1A4E7; B2RMP8; B7Z387; B7Z4Y6[Other Products]
UniProt Related Accession #
P05186[Other Products]
Molecular Weight
51,045 Da
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NCBI Official Full Name
alkaline phosphatase, tissue-nonspecific isozyme isoform 1 preproprotein
NCBI Official Synonym Full Names
alkaline phosphatase, liver/bone/kidney
NCBI Official Symbol
ALPL  [Similar Products]
NCBI Official Synonym Symbols
HOPS; TNAP; TNALP; APTNAP; TNSALP; AP-TNAP
  [Similar Products]
NCBI Protein Information
alkaline phosphatase, tissue-nonspecific isozyme
UniProt Protein Name
Alkaline phosphatase, tissue-nonspecific isozyme
UniProt Synonym Protein Names
Alkaline phosphatase liver/bone/kidney isozyme
Protein Family
Alkaline phosphatase
UniProt Gene Name
ALPL  [Similar Products]
UniProt Synonym Gene Names
AP-TNAP; TNSALP  [Similar Products]
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NCBI Summary for ALPL
This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]
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UniProt Comments for ALPL
This isozyme may play a role in skeletal mineralization.
Research Articles on ALPL
1. Mutations in ALPL which reduce alkaline phosphatase activity are responsible for Hypophosphatasia , a rare disorder characterized by defective bone and teeth mineralization and early tooth loss.
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Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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