CD23, Antibody

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 19; NC_000019.9 (7753643..7767032, complement). Location: 19p13.3

IgG1

LVNC-4

Mouse

Protein A/G Chromatography

Provided as sterile filtered solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein

Product should be stored at 4-8 degree C. DO NOT FREEZE

Small volumes of anti-CD23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

CD23 antigen is an integral membrane glycoprotein, Mr. 45 kdaltons The CD23 antigen is present on approximately all pre-B lymphocytes, plasma cells CD25 positive Ki-1 cells and HLA-DR. CD23 antigen is also expressed on Lymphoma, T Cell Lymphomas and B-CLLs. CD23 antigen is present on Hodgkin?s and Reed Sternberg cells).

Single-Color Reagent; Single Color Markers

Flow Cytometry (FC/FACS)

36,469 Da

Fc fragment of IgE, low affinity II, receptor for (CD23)

low affinity immunoglobulin epsilon Fc receptor; CD23 antigen; fc-epsilon-RII; lymphocyte IgE receptor; immunoglobulin E-binding factor; C-type lectin domain family 4, member J

Low affinity immunoglobulin epsilon Fc receptor

CD23A; CLEC4J; FCE2; IGEBF  [Similar Products]

FCER2_HUMAN

The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Function: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).

Subunit structure: Homotrimer. Ref.12

Subcellular location: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted. Note: Also exists as a soluble excreted form, sCD23. Ref.8 Ref.9

Post-translational modification: N- and O-glycosylated.The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.

Miscellaneous: There are two kinds of Fc receptors for IgE, which differ in both structure and function: high affinity receptors on basophils and mast cells and low affinity receptors on lymphocytes and monocytes.

Sequence similarities: Contains 1 C-type lectin domain.

Sequence caution: The sequence AAA52433.1 differs from that shown. Reason: Erroneous gene model prediction.

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