Product Name
CLCN5, Blocking Peptide
Full Product Name
CLCN5 Blocking Peptide (N-term)
Product Synonym Names
H(+)/Cl(-) exchange transporter 5; Chloride channel protein 5; ClC-5; Chloride transporter ClC-5; CLCN5; CLCK2
Product Gene Name
CLCN5 blocking peptide
[Similar Products]
Product Synonym Gene Name
CLCK2[Similar Products]
CLCN5 peptide (MBS9228765) is used for blocking the activity of CLCN5 antibody (MBS9214091)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51795
Specificity
The synthetic peptide sequence is selected from aa 30-41 of HUMAN CLCN5
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Tissue Location
Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of CLCN5 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CLCN5 blocking peptide
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
NCBI/Uniprot data below describe general gene information for CLCN5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000075.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000084.4
[Other Products]
UniProt Primary Accession #
P51795
[Other Products]
UniProt Secondary Accession #
Q5JQD5; Q7RTN8; A1L475; B3KPN6[Other Products]
UniProt Related Accession #
P51795[Other Products]
Molecular Weight
90,785 Da
NCBI Official Full Name
H(+)/Cl(-) exchange transporter 5 isoform b
NCBI Official Synonym Full Names
chloride voltage-gated channel 5
NCBI Official Symbol
CLCN5 [Similar Products]
NCBI Official Synonym Symbols
XRN; CLC5; XLRH; CLCK2; ClC-5; DENTS; NPHL1; NPHL2; hCIC-K2
[Similar Products]
NCBI Protein Information
H(+)/Cl(-) exchange transporter 5
UniProt Protein Name
H(+)/Cl(-) exchange transporter 5
UniProt Synonym Protein Names
Chloride channel protein 5; ClC-5; Chloride transporter ClC-5
Protein Family
H(+)/Cl(-) exchange transporter
UniProt Gene Name
CLCN5 [Similar Products]
UniProt Synonym Gene Names
CLCK2; ClC-5 [Similar Products]
UniProt Entry Name
CLCN5_HUMAN
NCBI Summary for CLCN5
This gene encodes a member of the ClC family of chloride ion channels and ion transporters. The encoded protein is primarily localized to endosomal membranes and may function to facilitate albumin uptake by the renal proximal tubule. Mutations in this gene have been found in Dent disease and renal tubular disorders complicated by nephrolithiasis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
UniProt Comments for CLCN5
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
Research Articles on CLCN5
1. Previously reported mutations and their associated phenotype in 377 male patients with Dent disease are reviewed and described phenotype and novel and recurrent mutations in a large cohort of 117 Dent disease patients belonging to 90 families.
Precautions
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Disclaimer
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