Product Name
gamma-glutamyl carboxylase (GGCX), Polyclonal Antibody
Full Product Name
Rabbit anti-human gamma-glutamyl carboxylase polyclonal Antibody
Product Synonym Names
gamma-glutamyl carboxylase; GGCX; FLJ26629; VKCFD1
Product Gene Name
anti-GGCX antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-79252 / sc-98671
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-GGCX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GGCX antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for GGCX. It may not necessarily be applicable to this product.
NCBI Accession #
AAA58643.1
[Other Products]
UniProt Secondary Accession #
Q14415; Q6GU45; B4DMC5; E9PEE1[Other Products]
UniProt Related Accession #
P38435[Other Products]
Molecular Weight
80,989 Da[Similar Products]
NCBI Official Full Name
gamma-glutamyl carboxylase
NCBI Official Synonym Full Names
gamma-glutamyl carboxylase
NCBI Official Symbol
GGCX [Similar Products]
NCBI Official Synonym Symbols
VKCFD1
[Similar Products]
NCBI Protein Information
vitamin K-dependent gamma-carboxylase; peptidyl-glutamate 4-carboxylase
UniProt Protein Name
Vitamin K-dependent gamma-carboxylase
UniProt Synonym Protein Names
Gamma-glutamyl carboxylase; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase
Protein Family
Vitamin K-dependent gamma-carboxylase
UniProt Gene Name
GGCX [Similar Products]
UniProt Synonym Gene Names
GC [Similar Products]
UniProt Entry Name
VKGC_HUMAN
NCBI Summary for GGCX
This gene encodes an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2008]
UniProt Comments for GGCX
GGCX: Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. Defects in GGCX are a cause of combined deficiency of vitamin K-dependent clotting factors type 1 (VKCFD1); also known as multiple coagulation factor deficiency III (MCFD3). VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. Defects in GGCX are the cause of pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency (PXEL-MCFD). This syndrome is characterized by hyperlaxity of the skin involving the entire body. Important phenotypic differences with classical PXE include much more severe skin laxity with spreading toward the trunk and limbs with thick, leathery skin folds rather than confinement to flexural areas, and no decrease in visual acuity. Moreover, detailed electron microscopic analyzes revealed that alterations of elastic fibers as well as their mineralization are slightly different from those in classic PXE. Belongs to the vitamin K-dependent gamma-carboxylase family.
Protein type: Ligase; Lyase; Membrane protein, integral; Membrane protein, multi-pass; EC 4.1.1.90
Chromosomal Location of Human Ortholog: 2p12
Cellular Component: endoplasmic reticulum membrane; membrane; integral to membrane
Molecular Function: gamma-glutamyl carboxylase activity
Biological Process: cellular protein metabolic process; protein modification process; post-translational protein modification; blood coagulation; peptidyl-glutamic acid carboxylation
Disease: Pseudoxanthoma Elasticum-like Disorder With Multiple Coagulation Factor Deficiency; Vitamin K-dependent Clotting Factors, Combined Deficiency Of, 1
Research Articles on GGCX
1. These findings indicate that individuals carrying the CYP2C19 rs3814637CC or CYP2C9 rs1057910AA or GGCX rs699664AA genotype needed higher warfarin doses in the Chinese population.
Precautions
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Disclaimer
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