Full Product Name
Goat anti-ABCG4 Antibody
Product Synonym Names
ABCG4; ATP-binding cassette, sub-family G (WHITE), member 4; WHITE2; ATP-binding cassette, subfamily G, member 4; putative ABC transporter; ABCG4 antibody; ATP-binding cassette; sub-family G (WHITE); member 4 antibody; WHITE2 antibody; ATP-binding cassette; subfamily G; member 4 antibody; putative ABC transporter antibody; ABCG4
Product Gene Name
anti-ABCG4 antibody
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Antibody/Peptide Pairs
ABCG4 peptide (MBS425316) is used for blocking the activity of ABCG4 antibody (MBS422232)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
YLVLRYRVKS ER
Species Reactivity
Expected from sequence similarity: Human, Mouse, Rat, Dog
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence C-YLVLRYRVKSER, from the C Terminus of the protein sequence according to NP_071452.2.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-ABCG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ABCG4 antibody
Peptide ELISA (EIA)
Application Notes for anti-ABCG4 antibody
Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Preliminary experiments in Human Brain (Cerebellum, Frontal Cortex, Hippocampus) and in Mouse Eye and Rat Retina lysates gave no specific signal but low background (at antibody concentration up to 1ug/ml).
NCBI/Uniprot data below describe general gene information for ABCG4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071452.2
[Other Products]
NCBI GenBank Nucleotide #
NM_022169.4
[Other Products]
UniProt Secondary Accession #
Q8WWH0; Q8WWH1; Q8WWH2; A8K1B5[Other Products]
UniProt Related Accession #
Q9H172[Other Products]
Molecular Weight
60,903 Da
NCBI Official Full Name
ATP-binding cassette sub-family G member 4
NCBI Official Synonym Full Names
ATP binding cassette subfamily G member 4
NCBI Official Symbol
ABCG4 [Similar Products]
NCBI Official Synonym Symbols
WHITE2
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NCBI Protein Information
ATP-binding cassette sub-family G member 4
UniProt Protein Name
ATP-binding cassette sub-family G member 4
Protein Family
ABC transporter G family
UniProt Gene Name
ABCG4 [Similar Products]
UniProt Synonym Gene Names
WHITE2 [Similar Products]
UniProt Entry Name
ABCG4_HUMAN
NCBI Summary for ABCG4
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCG4
ABCG4: May be involved in macrophage lipid homeostasis. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Protein type: Transporter; Membrane protein, integral; Transporter, ABC family; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: ATP binding; cholesterol transporter activity; protein binding; protein heterodimerization activity; protein homodimerization activity; sterol-transporting ATPase activity
Biological Process: cholesterol efflux; metabolic process; transmembrane transport
Research Articles on ABCG4
1. HUWE1 and NEDD4-1 are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 and ABCG4 protein levels and cellular cholesterol export activity
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
