Full Product Name
ABCG4 Antibody (N-term)
Product Synonym Names
ATP-binding cassette sub-family G member 4; ABCG4; WHITE2
Product Gene Name
anti-ABCG4 antibody
[Similar Products]
Antibody/Peptide Pairs
ABCG4 peptide (MBS9219351) is used for blocking the activity of ABCG4 antibody (MBS9201257)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence Positions
36-65
3D Structure
ModBase 3D Structure for Q9H172
Specificity
This ABCG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from the N-terminal region of human ABCG4.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Vial Concentration: 0.496 (lot specific)
Antigen Type
Synthetic Peptide
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-ABCG4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ABCG4 antibody
The protein encoded by this gene is included in the
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the White subfamily and is expressed
predominantly in liver tissue. The function has not yet been
determined but may involve cholesterol transport. Alternate splice
variants have been described but their full length sequences have
not been determined.
Product Categories/Family for anti-ABCG4 antibody
Cardiovascular; Metabolism; Neuroscience; Signal Transduction
Applications Tested/Suitable for anti-ABCG4 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-ABCG4 antibody
WB~~1:1000
Western Blot (WB) of anti-ABCG4 antibody
ABCG4 Antibody (N-term) western blot analysis in MDA-MB453,ZR-75-1 cell line lysates (35ug/lane).This demonstrates the ABCG4 antibody detected the ABCG4 protein (arrow).
NCBI/Uniprot data below describe general gene information for ABCG4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001135977.1
[Other Products]
NCBI Related Accession #
HumanNP_071452.2[Other Products]
NCBI GenBank Nucleotide #
NM_001142505.1
[Other Products]
UniProt Primary Accession #
Q9H172
[Other Products]
UniProt Secondary Accession #
Q8WWH0; Q8WWH1; Q8WWH2; A8K1B5[Other Products]
UniProt Related Accession #
Q9H172[Other Products]
NCBI Official Full Name
ATP-binding cassette sub-family G member 4
NCBI Official Synonym Full Names
ATP-binding cassette, sub-family G (WHITE), member 4
NCBI Official Symbol
ABCG4 [Similar Products]
NCBI Official Synonym Symbols
WHITE2
[Similar Products]
NCBI Protein Information
ATP-binding cassette sub-family G member 4
UniProt Protein Name
ATP-binding cassette sub-family G member 4
Protein Family
ABC transporter G family
UniProt Gene Name
ABCG4 [Similar Products]
UniProt Synonym Gene Names
WHITE2 [Similar Products]
UniProt Entry Name
ABCG4_HUMAN
NCBI Summary for ABCG4
The protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily and is expressed predominantly in liver tissue. The function has not yet been determined but may involve cholesterol transport. Alternate splice variants have been described but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for ABCG4
ABCG4: May be involved in macrophage lipid homeostasis. Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Protein type: Transporter, ABC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity; cholesterol transporter activity; ATPase activity; ATP binding
Biological Process: metabolic process; cholesterol efflux; transmembrane transport
Product References and Citations for anti-ABCG4 antibody
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Saito, A., et al. J. Hum. Genet. 54(6):317-323(2009)
Koshiba, S., et al. Xenobiotica 38 (7-8), 863-888 (2008) :
Research Articles on ABCG4
1. These results suggest that ABCA1, ABCG1, and ABCG4 are localized to distinct membrane meso-domains and disturb the meso-domain structures by reorganizing lipids on the plasma membrane
Precautions
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Disclaimer
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