Full Product Name
EXT2 antibody - N-terminal region
Product Gene Name
anti-EXT2 antibody
[Similar Products]
Product Synonym Gene Name
SOTV[Similar Products]
Antibody/Peptide Pairs
EXT2 peptide (MBS3232258) is used for blocking the activity of EXT2 antibody (MBS3207293)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: NELLMAISDS DYYTDDINRA CLFVPSIDVL NQNTLRIKET AQAMAQLSRW
3D Structure
ModBase 3D Structure for Q93063
Species Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Cow: 86%; Dog: 100%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 93%; Rabbit: 100%; Rat: 93%; Zebrafish: 79%
Immunogen
The immunogen is a synthetic peptide directed towards the N terminal region of human EXT2
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-EXT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-EXT2 antibody
This is a rabbit polyclonal antibody against EXT2. It was validated on Western Blot using a cell lysate as a positive control.
Target Description: EXT2 is one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis.This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Product Categories/Family for anti-EXT2 antibody
Polyclonal; Signal Proteins; Cell Cycle Proteins; Membrane Protein; Disease Related; Cell Differentiation;
Applications Tested/Suitable for anti-EXT2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Immunohistochemistry (IHC) of anti-EXT2 antibody
Rabbit Anti-EXT2 Antibody
Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue
Observed Staining: Cytoplasmic
Primary Antibody Concentration: N/A
Other Working Concentrations: 1:600
Secondary Antibody: Donkey anti-Rabbit-Cy3
Secondary Antibody Concentration: 1:200
Magnification: 20X
Exposure Time: 0.5 - 2.0 sec
Western Blot (WB) of anti-EXT2 antibody
Host: Rabbit
Target Name: EXT2
Sample Type: Human Hela
Antibody Dilution: 1.0ug/mlEXT2 is supported by BioGPS gene expression data to be expressed in HeLa
Western Blot (WB) of anti-EXT2 antibody
WB Suggested Anti-EXT2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: 721_B cell lysate
NCBI/Uniprot data below describe general gene information for EXT2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000392
[Other Products]
NCBI GenBank Nucleotide #
NM_000401
[Other Products]
UniProt Primary Accession #
Q93063
[Other Products]
UniProt Related Accession #
Q93063[Other Products]
NCBI Official Full Name
exostosin-2 isoform 1
NCBI Official Synonym Full Names
exostosin glycosyltransferase 2
NCBI Official Symbol
EXT2 [Similar Products]
NCBI Official Synonym Symbols
SOTV; SSMS
[Similar Products]
NCBI Protein Information
exostosin-2
UniProt Protein Name
Exostosin-2
UniProt Synonym Protein Names
Glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostoses protein 2; Putative tumor suppressor protein EXT2
UniProt Gene Name
EXT2 [Similar Products]
UniProt Entry Name
EXT2_HUMAN
NCBI Summary for EXT2
This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Research Articles on EXT2
1. The present study identified pathogenic mutations in 93% (68/73) of unrelated hereditary multiple osteochondromasprobands from 73 pedigrees. Mutations in EXT1 and EXT2 were identified in 53% (39/73) and 40% (29/73) of families.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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