Full Product Name
UNC13D Antibody
Product Gene Name
anti-UNC13D antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q70J99
Other Notes
Small volumes of anti-UNC13D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-UNC13D antibody
Western blot analysis UNC13D using HepG2 whole cell lysates
NCBI/Uniprot data below describe general gene information for UNC13D. It may not necessarily be applicable to this product.
NCBI Accession #
NP_954712.1
[Other Products]
NCBI GenBank Nucleotide #
NM_199242.2
[Other Products]
UniProt Primary Accession #
Q70J99
[Other Products]
UniProt Secondary Accession #
Q9H7K5; B4DWG9[Other Products]
UniProt Related Accession #
Q70J99[Other Products]
Molecular Weight
128,819 Da
NCBI Official Full Name
protein unc-13 homolog D
NCBI Official Synonym Full Names
unc-13 homolog D
NCBI Official Symbol
UNC13D [Similar Products]
NCBI Official Synonym Symbols
FHL3; HLH3; HPLH3; Munc13-4
[Similar Products]
NCBI Protein Information
protein unc-13 homolog D
UniProt Protein Name
Protein unc-13 homolog D
UniProt Synonym Protein Names
Munc13-4
UniProt Gene Name
UNC13D [Similar Products]
NCBI Summary for UNC13D
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder. [provided by RefSeq, Jul 2008]
UniProt Comments for UNC13D
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.
Research Articles on UNC13D
1. Gene-corrected human Munc13-4-deficient CD8+ T cells can efficiently restrict EBV-driven lymphoproliferation in immunodeficient mice
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
