Product Gene Name
anti-KHK antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P50053
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Protein
Other Notes
Small volumes of anti-KHK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-KHK antibody
Polyclonal
Applications Tested/Suitable for anti-KHK antibody
Western Blot (WB), Immunohistochemistry (IHC)
Western Blot (WB) of anti-KHK antibody
Western blot analysis of extracts of various cell lines, using KHK antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
Immunohistochemistry (IHC) of anti-KHK antibody
Immunohistochemistry of paraffin-embedded human kidney using KHK antibody at dilution of 1:100 (40x lens).
NCBI/Uniprot data below describe general gene information for KHK. It may not necessarily be applicable to this product.
NCBI Accession #
P50053.1
[Other Products]
UniProt Primary Accession #
P50053
[Other Products]
UniProt Secondary Accession #
Q6IBK2; Q99532; Q9BRJ3; Q9UMN1[Other Products]
UniProt Related Accession #
P50053[Other Products]
NCBI Official Full Name
Ketohexokinase
NCBI Official Synonym Full Names
ketohexokinase (fructokinase)
NCBI Official Symbol
KHK [Similar Products]
NCBI Protein Information
ketohexokinase; hepatic fructokinase
UniProt Protein Name
Ketohexokinase
UniProt Synonym Protein Names
Hepatic fructokinase
Protein Family
Ketohexokinase
UniProt Gene Name
KHK [Similar Products]
UniProt Entry Name
KHK_HUMAN
NCBI Summary for KHK
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for KHK
KHK iso2: Defects in KHK are the cause of fructosuria (FRUCT). Benign defect of intermediary metabolism. Belongs to the carbohydrate kinase PfkB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.3; Transferase
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: ketohexokinase activity; ATP binding
Biological Process: carbohydrate metabolic process; carbohydrate phosphorylation; pathogenesis; fructose catabolic process
Disease: Fructosuria, Essential
Research Articles on KHK
1. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.
Precautions
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Disclaimer
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