Full Product Name
KHK Antibody
Product Gene Name
anti-KHK antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of KHK
Calculated Molecular Weight: 298aa; 33kd
Observed Molecular Weight: 33-35kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-50029 / sc-366024
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-KHK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-KHK antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-KHK antibody
WB: 1:500-1:5000
Testing Data of anti-KHK antibody
NCBI/Uniprot data below describe general gene information for KHK. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006479.1
[Other Products]
NCBI GenBank Nucleotide #
NM_006488.2
[Other Products]
UniProt Secondary Accession #
Q6IBK2; Q99532; Q9BRJ3; Q9UMN1[Other Products]
UniProt Related Accession #
P50053[Other Products]
Molecular Weight
32,523 Da
NCBI Official Full Name
ketohexokinase isoform b
NCBI Official Synonym Full Names
ketohexokinase (fructokinase)
NCBI Official Symbol
KHK [Similar Products]
NCBI Protein Information
ketohexokinase; hepatic fructokinase
UniProt Protein Name
Ketohexokinase
UniProt Synonym Protein Names
Hepatic fructokinase
Protein Family
Ketohexokinase
UniProt Gene Name
KHK [Similar Products]
UniProt Entry Name
KHK_HUMAN
NCBI Summary for KHK
This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
UniProt Comments for KHK
KHK iso2: Defects in KHK are the cause of fructosuria (FRUCT). Benign defect of intermediary metabolism. Belongs to the carbohydrate kinase PfkB family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.3; Transferase
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: cytoplasm; nucleus; cytosol
Molecular Function: ketohexokinase activity; ATP binding
Biological Process: carbohydrate metabolic process; carbohydrate phosphorylation; pathogenesis; fructose catabolic process
Disease: Fructosuria, Essential
Research Articles on KHK
1. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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