Product Name
Prolactin (PRL), Active Protein
Popular Item
Full Product Name
Recombinant Rat Prolactin
Product Synonym Names
Rat Prolactin; Prolactin
Product Gene Name
PRL active protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MLPVCSGGDC QTPLPELFD R VVMLSHYI HT LYTDMFI EFD KQYVQD REFI AKAIN DCPTS SLAT PEDKEQ AQK VPPEVLLNLI LSLVHSW ND PLFQLITG L GGIHEAPDA IISRAKEIEE QNKRLLEGI E KIISQAYP EA KGNEIYL VWS QLPSLQ GVDE ESKDL AFYNNIRCLR RDSHK VDNY LKFLRC QIV HKNNC
3D Structure
ModBase 3D Structure for P01237
Purity/Purification
Purity is typically 97% as determined by reducing and non-reducing SDS-PAGE
Form/Format
Lyophilized from a sterile (0.2 micron) filtered aqueous solution containing
20 mM sodium phosphate, pH 7.5
Bioactivity Assay
bioactive protein but no acceptaince criteria limits established
Reconstitution
Sterile water at 0.1 mg/mL
Acceptance Criteria LAL (EUs/ug)
<=1.00
Endotoxin Level (kinetic LAL analysis)
Typically less than 0.05 EUs/mug protein (50% confidence range)
Biological Activity
The activity is determined by the ability to stimulate proliferation of NB2-11 cells and is typically less than 1 ng/mL. This corresponds to an expected specific activity of 1 x 106 units/mg.
Media Components
Luria Broth
Preparation and Storage
12 months from date of receipt when stored at -20 degree C to-80 degree C as supplied.
1 month when stored at 4 degree C after reconstituting as directed.
3 months when stored at -20 degree C to -80 degree C after reconstituting as directed.
Active Protein Note
Refer to the datasheet for activity details. For other activity applications, researchers should evaluate this protein for suitability in their model system.
Other Notes
Small volumes of PRL active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
PRL active protein
Prolactin (PRL) is a hormone that is produced and secreted by the pituitary gland. PRL acts in an endocrine, paracrine, and autocrine manner. The prolactin receptor (PRLR) is expressed on many cell types, including cells of the reproductive organs, central nervous system, and breast cancer. PRL signal transduction occurs via JAK kinase signaling pathways. The primary function of PRL is to regulate lactation, but PRL also plays functional roles in the immune system and during cell growth, apoptosis, and differentiation.
Gel Data of PRL active protein
Biological Activity of PRL active protein
NCBI/Uniprot data below describe general gene information for PRL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036761.1
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NCBI GenBank Nucleotide #
NM_012629.1
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UniProt Primary Accession #
P01237
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UniProt Secondary Accession #
P70520[Other Products]
UniProt Related Accession #
P01237[Other Products]
Molecular Weight
Non-glycosylated protein, containing 198 amino acids, with a molecular weight of 22.7 kDa.
NCBI Official Full Name
prolactin
NCBI Official Synonym Full Names
prolactin
NCBI Official Symbol
Prl [Similar Products]
NCBI Official Synonym Symbols
Gha1; PRLB; Prol; PRLSD1; Prl1a1; RNPROL; RATPRLSD1
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NCBI Protein Information
prolactin
UniProt Protein Name
Prolactin
UniProt Gene Name
Prl [Similar Products]
UniProt Synonym Gene Names
PRL [Similar Products]
NCBI Summary for PRL
induces lactation; may facilitate decidual growth and placentation; promotes prostate epithelial cell proliferation [RGD, Feb 2006]
UniProt Comments for PRL
prolactin: Prolactin acts primarily on the mammary gland by promoting lactation. Belongs to the somatotropin/prolactin family.
Protein type: Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17p12
Cellular Component: extracellular region; secretory granule
Molecular Function: hormone activity; prolactin receptor binding
Biological Process: cellular response to hormone stimulus; circadian rhythm; lactation; mammary gland development; maternal behavior; multicellular organismal response to stress; ovulation cycle; parturition; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of JAK-STAT cascade; regulation of JAK-STAT cascade; regulation of multicellular organism growth; regulation of ossification; response to drug; response to estradiol stimulus; response to ethanol; response to lipopolysaccharide; response to nutrient; response to organic cyclic substance; STAT protein nuclear translocation
Research Articles on PRL
1. This study demonstrated that the Cultured neurons expressed mRNA for both PRL and its receptor (PRLR), and both PRL and PRLR expression levels changed after the excitotoxic insult.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
