Product Name
MAP-2 (2a + 2b) Microtubule Associated Protein 2 (MAP2), Monoclonal Antibody
Full Product Name
MAb to MAP-2 (2a + 2b)
Product Synonym Names
Monoclonal Antibody to Microtubule Associated Protein-2 (MAP-2) (2a + 2b)
Product Gene Name
anti-MAP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 2; NC_000002.11 (210288771..210598834). Location: 2q34-q35
3D Structure
ModBase 3D Structure for P11137
Host
Host: Mouse
Source: Cell Culture
Specificity
MAP-2 (2a + 2b) Microtubule Associated Protein 2
Recognizes (Mr 300kDa) MAP-2 protein from bovine brain and dendrites and cell bodies of neurons. Strongly cross-reacts with MAP-2 from human, rat, mouse and chicken brains. Reacts with the high molecular
Purity/Purification
Protein G chromatography. Fluorescein which has a maximum absorbance at 492nm and an emission maximum at 518nm has been covalently attached to Anti-MAP-2 and purified to assure optimal fluorochrome/protein (F/P) molar ratios.
Concentration
100ug/ml (OD280nm) (lot specific)
Affinity Constant
Not determined
Buffer
0.01M PBS, pH 7.4 containing 1% BSA
Preservative
0.09% Sodium azide
Important Note
Centrifuge before opening to ensure complete recovery of vial contents.
Warnings
This product contains sodium azide, which has been classified as Xn (Harmful) in European Directive 67/548/EEC in the concentration range of 0.1-1.0%. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Preparation and Storage
Store (protected from light) at 2 to 8 degree C. DO NOT FREEZE!
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-MAP2 antibody
Monoclonal Antibodies for Neuroscience
Applications Tested/Suitable for anti-MAP2 antibody
Immunohistochemistry - Formalin
Application Notes for anti-MAP2 antibody
Can be used in protein blotting and immunohistochemistry, frozen tissues only. The suggested working dilution for immunohistochemical staining is approximately 1:500. Each laboratory should determine an optimum working titer for use in its particular appl
NCBI/Uniprot data below describe general gene information for MAP2. It may not necessarily be applicable to this product.
NCBI Accession #
P11137.4
[Other Products]
UniProt Primary Accession #
P11137
[Other Products]
UniProt Secondary Accession #
Q17S04; Q99975; Q99976[Other Products]
UniProt Related Accession #
P11137; Q16296; Q59FX9; Q6NYC5; Q8IUX2[Other Products]
Molecular Weight
199,526 Da[Similar Products]
NCBI Official Full Name
Microtubule-associated protein 2
NCBI Official Synonym Full Names
microtubule-associated protein 2
NCBI Official Symbol
MAP2 [Similar Products]
NCBI Official Synonym Symbols
MAP2A; MAP2B; MAP2C; DKFZp686I2148
[Similar Products]
NCBI Protein Information
microtubule-associated protein 2; MAP-2; OTTHUMP00000163915; OTTHUMP00000163916; OTTHUMP00000165185; OTTHUMP00000208143; OTTHUMP00000208144
UniProt Protein Name
Microtubule-associated protein 2
Protein Family
Microtubule-associated protein
UniProt Gene Name
MAP2 [Similar Products]
UniProt Entry Name
MAP2_HUMAN
NCBI Summary for MAP2
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq]
UniProt Comments for MAP2
Function: The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Subcellular location: Cytoplasm › cytoskeleton
Probable.
Post-translational modification: MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.9 Ref.10 Ref.11 Ref.12
Sequence similarities: Contains 3 Tau/MAP repeats.
Product References and Citations for anti-MAP2 antibody
• Cacares, A. et al., (1984), J. Neuroscience, 4:394.
• Peng, I. et al., (1986), J. Cell Biol., 102:252.
• Lewis, S.A. et al., (1989), Nature, 342:498
Research Articles on MAP2
1. Increased MAP2 expression in malignant melanoma cells significantly inhibits tumor cell growth and neoplasm invasiveness, and induces apoptosis and cell cycle arrest.
Precautions
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Disclaimer
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