HCLS1 associated protein X-1, ELISA Kit

Mouse HCLS1-associated protein X-1 (HAX1) ELISA kit; RP11-137P24.1; FLJ17042; FLJ18492; FLJ93803; HCLSBP1; HS1BP1; SCN3; HCLS1 (and PKD2) associated protein; HS1 binding protein; HCLS1 associated protein X-1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of HAX1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9316233 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the HCLS1 associated protein X-1 (HAX1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing HAX1. The ELISA analytical biochemical technique of the MBS9316233 kit is based on HAX1 antibody-HAX1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect HAX1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, HAX1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

31,654 Da

HCLS1 associated X-1

HCLS1-associated protein X-1; HS1 binding protein; HS1-associated protein X-1; HS1-associating protein X-1

HCLS1-associated protein X-1

Hs1bp1; HAX-1; HSP1BP-1  [Similar Products]

HAX1_MOUSE

HAX1: Promotes cell survival. Potentiates GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. May regulate intracellular calcium pools. Defects in HAX1 are the cause of neutropenia severe congenital autosomal recessive type 3 (SCN3); also known as Kostmann disease. A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. Some patients affected by severe congenital neutropenia type 3 have neurological manifestations such as psychomotor retardation and seizures. The clinical phenotype due to HAX1 deficiency appears to depend on the localization of the mutations and their influence on the transcript variants. Mutations affecting exclusively isoform 1 are associated with isolated congenital neutropenia, whereas mutations affecting both isoform 1 and isoform 5 are associated with additional neurologic symptoms. Belongs to the HAX1 family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Mitochondrial; Vesicle; Apoptosis

Cellular Component: mitochondrion; intracellular membrane-bound organelle; clathrin-coated vesicle; sarcoplasmic reticulum; endoplasmic reticulum; actin cytoskeleton; transcription factor complex; membrane; lamellipodium; apical plasma membrane; cytoplasm; cytoplasmic vesicle; nucleus

Molecular Function: protein domain specific binding; protein binding; protein N-terminus binding; interleukin-1 binding

Biological Process: positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; regulation of actin filament polymerization; positive regulation of peptidyl-tyrosine phosphorylation; cell surface receptor linked signal transduction; positive regulation of granulocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation

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