High Mobility Group AT Hook Protein 2 (HMGA2), Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_000076.6 (120361275..120476935, complement). Location: 10 D2; 10 67.94 cM

E Coli

> 95%

Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.

Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of HMGA2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

15.6kDa

high mobility group AT-hook 2

high mobility group protein HMGI-C; high mobility group AT-hook protein 2; high mobility group protein I, isoform C

High mobility group protein HMGI-C

Hmgic  [Similar Products]

HMGA2_MOUSE

HMGA2: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Oncoprotein

Cellular Component: nuclear chromosome; chromatin; nucleus

Molecular Function: protein binding; enzyme binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA binding; AT DNA binding

Biological Process: transcription from RNA polymerase II promoter; somatic stem cell maintenance; cell proliferation in forebrain; negative regulation of transcription from RNA polymerase II promoter; positive regulation of multicellular organism growth; signal transduction; regulation of growth hormone secretion; meiotic cell cycle; regulation of transcription, DNA-dependent; base-excision repair; regulation of growth; positive regulation of cell proliferation; mitosis; negative regulation of steroid hormone receptor signaling pathway; transcription, DNA-dependent; adrenal gland development; male gonad development; cell cycle; DNA catabolic process, endonucleolytic; chromosome condensation; cell proliferation; cell division; pituitary gland development; negative regulation of astrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; spermatogenesis; negative regulation of JAK-STAT cascade

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