FOXG1, Polyclonal Antibody

Forkhead box G1; Brain factor 1; Brain factor 2; BF1; BF2; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; Forkhead box protein G1; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF2; HBF-3; HBF-G2; HFK1; HFK2; HFK3; KHL2; QIN ; forkhead box G1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

FOXG1 antibody is human, mouse and rat reactive.

FOXG1 antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL (lot specific)

FOXG1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

Small volumes of anti-FOXG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

FOXG1 belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain and plays an important role in the development of the brain and telencephalon (1). It is essential for the proliferation of progenitor cells in the cerebral cortex and influences regional patterning in the mammalian telencephalon (2,3). Expression is restricted to the neurons of the developing telencephalon (3). The loss of FOXG1 results in an accelerated rate of neuronal differentiation and the shortening of the neurogenetic period in the embryonic cerebral cortex (2,4).

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

FOXG1 antibody can be used for detection of FOXG1 by Western blot at 1 - 2 mug/ml. For immunofluorescence start at 20 mug/mL.

Western blot analysis of FOXG1 in rat brain tissue lysate with FOXG1 antibody at 1 μg/ml.

Immunofluorescence of FOXG1 in mouse brain tissue with FOXG1 antibody at 20 μg/ml.

Predicted: 54 kDa

Observed: 54 kDa

forkhead box G1

forkhead box protein G1; oncogene QIN; brain factor 1; brain factor 2; forkhead-like 1; forkhead-like 2; forkhead-like 3; forkhead-like 4

Forkhead box protein G1

FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1A; FOXG1B; FOXG1C; BF-1; BF1; BF-2; BF2; hBF-2; HFK1; HFK2; HFK3  [Similar Products]

FOXG1_HUMAN

This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]

FOXG1: Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. Interacts with KDM5B. Expression is restricted to the neurons of the developing telencephalon.

Protein type: DNA-binding; Nuclear receptor co-regulator; Transcription factor

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: nucleus

Molecular Function: protein binding; DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: transcription, DNA-dependent; brain development; negative regulation of transcription, DNA-dependent; aging

Disease: Rett Syndrome, Congenital Variant

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