Product Name
Cadherin-23 (CDH23), Polyclonal Antibody
Full Product Name
Cadherin-23 Polyclonal Antibody
Product Gene Name
anti-CDH23 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9H251
Other Notes
Small volumes of anti-CDH23 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CDH23. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001165401.1
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NCBI GenBank Nucleotide #
NM_001171930.1
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UniProt Primary Accession #
Q9H251
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UniProt Secondary Accession #
Q5QGS1; Q5QGS2; Q5QGS5; Q5QGS6; Q5XKN2; Q6UWW1; Q96JL3; Q9H4K9; C4IXS9; F6U049[Other Products]
UniProt Related Accession #
Q9H251[Other Products]
Molecular Weight
23,900 Da[Similar Products]
NCBI Official Full Name
cadherin-23 isoform 3
NCBI Official Synonym Full Names
cadherin related 23
NCBI Official Symbol
CDH23 [Similar Products]
NCBI Official Synonym Symbols
PITA5; USH1D; CDHR23
[Similar Products]
NCBI Protein Information
cadherin-23
UniProt Protein Name
Cadherin-23
UniProt Synonym Protein Names
Otocadherin
UniProt Gene Name
CDH23 [Similar Products]
NCBI Summary for CDH23
This gene is a member of the cadherin superfamily, whose genes encode calcium dependent cell-cell adhesion glycoproteins. The encoded protein is thought to be involved in stereocilia organization and hair bundle formation. The gene is located in a region containing the human deafness loci DFNB12 and USH1D. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of this cadherin-like gene. Upregulation of this gene may also be associated with breast cancer. Alternative splice variants encoding different isoforms have been described. [provided by RefSeq, May 2013]
UniProt Comments for CDH23
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
Research Articles on CDH23
1. data suggest that CDH23-C is a CAMSAP3/Marshalin-binding protein that can modify MT networks indirectly through its interaction with CAMSAP3/Marshalin.
Precautions
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Disclaimer
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