Product Name
KCNIP2, Polyclonal Antibody
Full Product Name
Anti-KCNIP2 Antibody
Product Gene Name
anti-KCNIP2 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NS61
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purification
Concentration
1mg/ml (lot specific)
Immunogen
Recombinant protein of human KCNIP2
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-KCNIP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KCNIP2 antibody
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins.
Applications Tested/Suitable for anti-KCNIP2 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KCNIP2 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for KCNIP2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_775289.1
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NCBI GenBank Nucleotide #
NM_173197.2
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UniProt Primary Accession #
Q9NS61
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UniProt Secondary Accession #
Q3YAC6; Q3YAC8; Q3YAC9; Q7Z6F1; Q96K86; Q96T41; Q96T42; Q96T43; Q96T44; A6NJE5; A8MQ75[Other Products]
UniProt Related Accession #
Q9NS61[Other Products]
Molecular Weight
21,401 Da
NCBI Official Full Name
Kv channel-interacting protein 2 isoform 7
NCBI Official Synonym Full Names
potassium voltage-gated channel interacting protein 2
NCBI Official Symbol
KCNIP2 [Similar Products]
NCBI Official Synonym Symbols
KCHIP2
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NCBI Protein Information
Kv channel-interacting protein 2
UniProt Protein Name
Kv channel-interacting protein 2
UniProt Synonym Protein Names
A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2
Protein Family
Kv channel-interacting protein
UniProt Gene Name
KCNIP2 [Similar Products]
UniProt Synonym Gene Names
KCHIP2; KChIP2 [Similar Products]
NCBI Summary for KCNIP2
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNIP2
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart ().
Research Articles on KCNIP2
1. although there is a baseline presence of KChIP2 in the nucleus both in vivo and in vitro, KChIP2 does not directly regulate transcriptional activity. Moreover, the nuclear transport of KChIP2 is not dependent on Ca(2+). Thus, KChIP2 does not function as a conventional transcription factor in the heart.
Precautions
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Disclaimer
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