Product Name
KCNIP2, cDNA Clone
Full Product Name
KCNIP2 cDNA Clone
Product Gene Name
KCNIP2 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgcggggcc agggccgcaa ggagagtttg tccgattccc gagacctgga cggctcctac gaccagctca cgggccaccc tccagggccc actaaaaaag cgctgaagca gcgattcctc aagctgctgc cgtgctgcgg gccccaagcc ctgccctcag tcagtgaaaa cagcgtggac gatgaatttg aattgtccac cgtgtgtcac cggcctgagg gtctggagca gctgcaggag caaaccaaat tcacgcgcaa ggagttgcag gtcctgtacc ggggcttcaa gaacgaatgt cccagcggaa ttgtcaatga ggagaacttc aagcagattt actcccagtt ctttcctcaa ggagactcca gcacctatgc cacttttctc ttcaatgcct ttgacaccaa ccatgatggc tcggtcagtt ttgaggactt tgtggctggt ttgtccgtga ttcttcgggg aactgtagat gacaggctta attgggcctt caacctgtat gaccttaaca aggacggctg catcaccaag gaggaaatgc ttgacatcat gaagtccatc tatgacatga tgggcaagta cacgtaccct gcactccggg aggaggcccc aagggaacac gtggagagct tcttccagaa gatggacaga aacaaggatg gtgtggtgac cattgaggaa ttcattgagt cttgtcaaaa ggatgagaac atcatgaggt ccatgcagct ctttgacaat gtcatctag
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of KCNIP2 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for KCNIP2. It may not necessarily be applicable to this product.
NCBI Accession #
BC034685
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UniProt Secondary Accession #
Q3YAC6; Q3YAC8; Q3YAC9; Q7Z6F1; Q96K86; Q96T41; Q96T42; Q96T43; Q96T44; A6NJE5; A8MQ75[Other Products]
UniProt Related Accession #
Q9NS61[Other Products]
Molecular Weight
21,401 Da
NCBI Official Full Name
Homo sapiens Kv channel interacting protein 2, mRNA
NCBI Official Synonym Full Names
potassium voltage-gated channel interacting protein 2
NCBI Official Symbol
KCNIP2 [Similar Products]
NCBI Official Synonym Symbols
KCHIP2
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NCBI Protein Information
Kv channel-interacting protein 2
UniProt Protein Name
Kv channel-interacting protein 2
UniProt Synonym Protein Names
A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2
Protein Family
Kv channel-interacting protein
UniProt Gene Name
KCNIP2 [Similar Products]
UniProt Synonym Gene Names
KCHIP2; KChIP2 [Similar Products]
UniProt Entry Name
KCIP2_HUMAN
NCBI Summary for KCNIP2
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNIP2
KCNIP2: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Belongs to the recoverin family. 9 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: cytoplasm; plasma membrane; voltage-gated potassium channel complex
Molecular Function: A-type (transient outward) potassium channel activity; calcium ion binding; potassium channel regulator activity; protein binding; protein N-terminus binding
Biological Process: clustering of voltage-gated potassium channels; detection of calcium ion; potassium ion transport; regulation of heart contraction; signal transduction
Research Articles on KCNIP2
1. A novel KCNQ1-G229D mutation identified in a juvenile-onset AF patient altered the IKs activity and kinetics, thereby increasing the arrhythmogenicity to AF.
Precautions
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Disclaimer
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