Full Product Name
GORAB Antibody
Product Synonym Names
FLJ11752; GO; MGC51263; MGC70512; NTKLBP1; SCYL1BP1
Product Gene Name
anti-GORAB antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of GORAB
Calculated Molecular Weight: 264aa; 28kd; 394aa; 45kd
Observed Molecular Weight: 45-50kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-160088
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-GORAB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GORAB antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-GORAB antibody
WB: 1:500-1:5000
Testing Data of anti-GORAB antibody
NCBI/Uniprot data below describe general gene information for GORAB. It may not necessarily be applicable to this product.
NCBI Accession #
AAH47476.1
[Other Products]
UniProt Secondary Accession #
Q49A22; Q6P1P9; Q9HAE6; Q9Y350[Other Products]
UniProt Related Accession #
Q5T7V8[Other Products]
Molecular Weight
24,652 Da
NCBI Official Full Name
GORAB protein
NCBI Official Synonym Full Names
golgin, RAB6-interacting
NCBI Official Symbol
GORAB [Similar Products]
NCBI Official Synonym Symbols
GO; NTKLBP1; SCYL1BP1
[Similar Products]
NCBI Protein Information
RAB6-interacting golgin; N-terminal kinase-like-binding protein 1; NTKL-binding protein 1; SCY1-like 1 binding protein 1; SCY1-like 1-binding protein 1; SCYL1-BP1; SCYL1-binding protein 1; hNTKL-BP1
UniProt Protein Name
RAB6-interacting golgin
UniProt Synonym Protein Names
N-terminal kinase-like-binding protein 1; NTKL-BP1; NTKL-binding protein 1; hNTKL-BP1; SCY1-like 1-binding protein 1; SCYL1-BP1; SCYL1-binding protein 1
Protein Family
RAB6-interacting golgin
UniProt Gene Name
GORAB [Similar Products]
UniProt Synonym Gene Names
NTKLBP1; SCYL1BP1; NTKL-BP1; NTKL-binding protein 1; hNTKL-BP1; SCYL1-BP1; SCYL1-binding protein 1 [Similar Products]
UniProt Entry Name
GORAB_HUMAN
NCBI Summary for GORAB
This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
UniProt Comments for GORAB
SCYL1BP1: Defects in GORAB are the cause of geroderma osteodysplasticum (GO); also known as gerodermia osteodysplastica or Walt Disney dwarfism. GO is a rare autosomal recessive disorder characterized by lax, wrinkled skin, joint laxity and a typical face with a prematurely aged appearance. Skeletal signs include severe osteoporosis leading to frequent fractures, malar and mandibular hypoplasia and a variable degree of growth retardation. Belongs to the GORAB family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 1q24.2
Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleolus; nucleus
Molecular Function: protein binding
Disease: Geroderma Osteodysplasticum
Research Articles on GORAB
1. Data suggest that SCYL1-BP1 is a novel regulator of the MDM2-p53 feedback loop and that it may be a potential tumor suppressor.
Precautions
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Disclaimer
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