Product Name
Neurogenin 3 (NEUROG3), Polyclonal Antibody
Full Product Name
Neurogenin 3 Antibody
Product Synonym Names
Neurogenin 3
Product Gene Name
anti-NEUROG3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 10; NC_000010.10 (71331791..71333210, complement). Location: 10q21.3
3D Structure
ModBase 3D Structure for Q9Y4Z2
Specificity
This Polyclonal antibody is directed against human Neurogenin 3 protein. The product was purified from serum by protein A chromatography. Expect reactivity with human Neurogenin 3. Cross-reactivity with Neurogenin 3 from other sources has not been determined.
Purity/Purification
Affinity purified
Concentration
100ug/100ul (lot specific)
Immunogen
Synthetic peptide derived from Human Neurogenin 3.
Storage Buffer
PBS, pH 7.4 with 0.02% sodium azide.
Preparation and Storage
This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Other Notes
Small volumes of anti-NEUROG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NEUROG3 antibody
Neurogenin 3 is a Rabbit polyclonal to Neurogenin 3
Applications Tested/Suitable for anti-NEUROG3 antibody
Western Blot (WB)
Western Blot (WB) of anti-NEUROG3 antibody
NCBI/Uniprot data below describe general gene information for NEUROG3. It may not necessarily be applicable to this product.
NCBI Accession #
ADM86144.1
[Other Products]
UniProt Primary Accession #
Q9Y4Z2
[Other Products]
UniProt Secondary Accession #
Q5VVI0; Q6DJX6; Q9BY24[Other Products]
UniProt Related Accession #
Q9Y4Z2[Other Products]
Molecular Weight
23,077 Da[Similar Products]
NCBI Official Full Name
neurogenin 3
NCBI Official Synonym Full Names
neurogenin 3
NCBI Official Symbol
NEUROG3 [Similar Products]
NCBI Official Synonym Symbols
ngn3; Atoh5; NGN-3; Math4B; bHLHa7
[Similar Products]
NCBI Protein Information
neurogenin-3; protein atonal homolog 5; class A basic helix-loop-helix protein 7
UniProt Protein Name
Neurogenin-3
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 7; bHLHa7; Protein atonal homolog 5
Protein Family
Neurogenin
UniProt Gene Name
NEUROG3 [Similar Products]
UniProt Synonym Gene Names
ATOH5; BHLHA7; NGN3; NGN-3; bHLHa7 [Similar Products]
UniProt Entry Name
NGN3_HUMAN
NCBI Summary for NEUROG3
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
UniProt Comments for NEUROG3
Function: Acts as a transcriptional regulator. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types
By similarity.
Subunit structure: Efficient DNA binding requires dimerization with another bHLH protein
By similarity.
Subcellular location: Nucleus
Potential.
Involvement in disease: Diarrhea 4, malabsorptive, congenital (DIAR4) [MIM:610370]: A disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7
Sequence similarities: Contains 1 bHLH (basic helix-loop-helix) domain.
Research Articles on NEUROG3
1. Data indicate associations of SNPs in eight loci CXCR4, HHEX, FOXA2, NGN3, TCF7L2, FLJ39370 (C4orf32), LOC646279 (RPL21P7) and THADA with body mass index (BMI) and weight.
Precautions
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Disclaimer
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