Full Product Name
Anti-CETP antibody
Product Synonym Names
Cholesteryl ester transfer protein; cholesteryl ester transfer protein, plasma; BPIFF antibody; CETP antibody; CETP_HUMAN antibody; Cholesteryl ester transfer antibody; Cholesteryl ester transfer protein antibody; Cholesteryl ester transfer protein plasma antibody; Cholesteryl ester transfer protein precursor antibody; HDLCQ10 antibody; Lipid transfer protein I antibody
Product Gene Name
anti-CETP antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11597
Purity/Purification
Immunogen affinity purified.
Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human CETP (368-382aa PRPDQQHSVAYTFEE).
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CETP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CETP antibody
Description: Rabbit IgG polyclonal antibody for Cholesteryl ester transfer protein(CETP) detection. Tested with WB in Human.
Background: CETP(Cholesteryl Ester Transfer Protein Plasma), is a plasma protein that facilitates the transport of cholesteryl esters and triglycerides between the lipoproteins. CETP is also known as lipid transfer protein I(Day et al., 1994). Sparkes et al.(1987) used a CETP probe against DNA from a human/mouse somatic cell hybrid panel to assign the CETP gene to chromosome 16. Because the role of CETP in atherosclerosis remained unclear, Okamoto et al.(2000) attempted to develop a potent, specific CETP inhibitor. One inhibitor, JTT-705, forms a disulfide bond with CETP and increases high density lipoprotein(HDL) cholesterol, decreases non-HDL cholesterol, and inhibits the progression of atherosclerosis in rabbits.
Applications Tested/Suitable for anti-CETP antibody
Western Blot (WB)
Western Blot (WB) of anti-CETP antibody
Anti-CETP antibody, MBS176257, Western blotting
Lane 1: HELA Cell Lysate
Lane 2: COLO320 Cell Lysate
Lane 3: HT1080 Cell Lysate
Lane 4: JURKAT Cell Lysate
Lane 5: RAJI Cell Lysate
Lane 6: MCF-7 Cell Lysate
NCBI/Uniprot data below describe general gene information for CETP. It may not necessarily be applicable to this product.
NCBI Accession #
P11597.2
[Other Products]
UniProt Primary Accession #
P11597
[Other Products]
UniProt Secondary Accession #
Q13987; Q13988; Q53YZ1[Other Products]
UniProt Related Accession #
P11597[Other Products]
Molecular Weight
47,787 Da
NCBI Official Full Name
Cholesteryl ester transfer protein
NCBI Official Synonym Full Names
cholesteryl ester transfer protein, plasma
NCBI Official Symbol
CETP [Similar Products]
NCBI Official Synonym Symbols
BPIFF; HDLCQ10
[Similar Products]
NCBI Protein Information
cholesteryl ester transfer protein; lipid transfer protein I; BPI fold containing family F
UniProt Protein Name
Cholesteryl ester transfer protein
UniProt Synonym Protein Names
Lipid transfer protein I
Protein Family
Cholesteryl ester transfer protein
UniProt Gene Name
CETP [Similar Products]
UniProt Entry Name
CETP_HUMAN
NCBI Summary for CETP
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
UniProt Comments for CETP
CETP: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1). Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid-binding; Secreted; Secreted, signal peptide; Vesicle
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: extracellular space; extracellular region; vesicle
Molecular Function: lipid transporter activity; phospholipid transporter activity; cholesterol transporter activity; cholesterol binding; phosphatidylcholine binding; lipid binding; triglyceride binding
Biological Process: cholesterol metabolic process; receptor-mediated endocytosis; cholesterol transport; lipid homeostasis; lipoprotein metabolic process; lipid transport; phosphatidylcholine metabolic process; cholesterol homeostasis; reverse cholesterol transport; triacylglycerol metabolic process; phospholipid transport; triacylglycerol transport; transmembrane transport; phospholipid homeostasis
Disease: Hyperalphalipoproteinemia 1
Research Articles on CETP
1. Variants with CETP conferred susceptibility to CAD in overweight individuals.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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