Product Name
ALDH1A1, Polyclonal Antibody
Full Product Name
ALDH1A1 Antibody FITC-Conjugated
Product Synonym Names
Acetaldehyde dehydrogenase 1; AHD2; ALDC; Aldehyde dehydrogenase 1 family member A1; Aldehyde dehydrogenase 1 soluble; Aldehyde dehydrogenase 1A1; Aldehyde dehydrogenase; Aldehyde dehydrogenase cytosolic; Aldehyde dehydrogenase liver cytosolic; ALDH 1; ALDH 1A1; ALDH class 1; ALDH, liver cytosolic; ALDH-E1; ALDH1; ALDH11; ALDH1A1; ALHDII; epididymis luminal protein 12; epididymis luminal protein 9; epididymis secretory sperm binding protein Li 53e; HEL-S-53e; MGC2318; PUMB1; RALDH 1; Retinal dehydrogenase 1 antibody
Product Gene Name
anti-ALDH1A1 antibody
[Similar Products]
Antibody/Peptide Pairs
ALDH1A1 peptide (MBS542347) is used for blocking the activity of ALDH1A1 antibody (MBS540961)
Matching Pairs
Antibody: ALDH1A1 (MBS540961)
Positive Control: ALDH1A1 (MBS542516)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P51647
Form/Format
FITC-Conjugated
Concentration
0.5-1.5 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 441-491 on rat retinal dehydrogenase 1 protein.
Expression
Strongly expressed in kidney, lung, testis, intestine, stomach, and trachea, but weakly in the liver.
Molecular Function
Oxidoreductase
Structure
Belongs to the aldehyde dehydrogenase family.
Subcellular Location
Cytoplasm
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-ALDH1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ALDH1A1 antibody
FITC-Conjugated Aldehyde Dehydrogenase family 1 member A1 Antibody
Is capable of converting 9-cis and all-trans retinal to corresponding retinoic acid with high efficiency, 9-cis retinal being 2-fold more active than all-trans retinal.
Applications Tested/Suitable for anti-ALDH1A1 antibody
ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-ALDH1A1 antibody
ELISA: 1:50,000
Immunoprecipitation: 1:200
Western Blot: 1:2,500-1:5,000
NCBI/Uniprot data below describe general gene information for ALDH1A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_071852
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NCBI GenBank Nucleotide #
NM_022407.3
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UniProt Primary Accession #
P51647
[Other Products]
UniProt Secondary Accession #
O09184[Other Products]
UniProt Related Accession #
P51647[Other Products]
Molecular Weight
54,459 Da
NCBI Official Full Name
retinal dehydrogenase 1
NCBI Official Synonym Full Names
aldehyde dehydrogenase 1 family, member A1
NCBI Official Symbol
Aldh1a1 [Similar Products]
NCBI Official Synonym Symbols
Ahd2; Aldh1; Aldh2
[Similar Products]
NCBI Protein Information
retinal dehydrogenase 1
UniProt Protein Name
Retinal dehydrogenase 1
UniProt Synonym Protein Names
ALDH-E1; ALHDII; Aldehyde dehydrogenase family 1 member A1; Aldehyde dehydrogenase, cytosolic
Protein Family
Retinal dehydrogenase
UniProt Gene Name
Aldh1a1 [Similar Products]
UniProt Synonym Gene Names
Aldh; RALDH 1; RalDH1 [Similar Products]
UniProt Entry Name
AL1A1_RAT
NCBI Summary for ALDH1A1
ubiquitous enzyme located in virtually all mammalian tissues; catalyzes oxidation of aldehyde substrates to carboxylic acids; detoxifies ethanol-derived acetaldehyde [RGD, Feb 2006]
UniProt Comments for ALDH1A1
ALDH1A1: Binds free retinal and cellular retinol-binding protein- bound retinal. Can convert/oxidize retinaldehyde to retinoic acid. Belongs to the aldehyde dehydrogenase family.
Protein type: Oxidoreductase; GAPs; EC 1.2.1.36; Cofactor and Vitamin Metabolism - retinol; GAPs, Ras; Apoptosis
Cellular Component: cytoplasm; nucleus
Molecular Function: 3-chloroallyl aldehyde dehydrogenase activity; aldehyde dehydrogenase (NAD) activity; benzaldehyde dehydrogenase (NAD+) activity; identical protein binding; retinal dehydrogenase activity
Biological Process: 9-cis-retinoic acid biosynthetic process; 9-cis-retinoic acid metabolic process; embryonic eye morphogenesis; kidney development; liver development; midgut development; optic cup morphogenesis involved in camera-type eye development; positive regulation of apoptosis; protein homotetramerization; response to drug; response to estradiol stimulus; response to ethanol; response to organic cyclic substance; response to oxidative stress; response to retinoic acid; retinoic acid metabolic process; retinol metabolic process
Research Articles on ALDH1A1
1. Overexpression and inhibition of ALDH1A1 activity results in reduced and increased HNE toxicity, respectively.
Precautions
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Disclaimer
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