Neurogenin 3 (NEUROG3), Polyclonal Antibody

Math4B; Atoh5; ngn3; bHLHa7; Class A basic helix-loop-helix protein 7; Protein atonal homolog 5

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

200ug/ml (lot specific)

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-NEUROG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC)

23,077 Da

neurogenin 3

neurogenin-3

Neurogenin-3

ATOH5; BHLHA7; NGN3; NGN-3; bHLHa7  [Similar Products]

The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]

neurogenin 3: Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4). DIAR4 is a characterized by severe, life- threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.

Protein type: Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: cytoplasm; nucleus

Molecular Function: chromatin DNA binding; protein binding; protein dimerization activity; transcription coactivator activity

Biological Process: central nervous system development; endocrine pancreas development; epithelial cell differentiation; forebrain development; hindbrain development; negative regulation of transcription from RNA polymerase II promoter; nervous system development; peripheral nervous system development; positive regulation of neuron differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; regulation of dendrite morphogenesis; spinal cord development; transcription from RNA polymerase II promoter

Disease: Diarrhea 4, Malabsorptive, Congenital

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