Full Product Name
Goat anti-GABRG2 Antibody
Product Synonym Names
GABRG2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; CAE2; ECA2; GEFSP3; GABA(A) receptor subunit gamma-2; gamma-aminobutyric acid receptor subunit gamma-2
Product Gene Name
anti-GABRG2 antibody
[Similar Products]
Antibody/Peptide Pairs
GABRG2 peptide (MBS428792) is used for blocking the activity of GABRG2 antibody (MBS423750)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P18507
Species Reactivity
Rat
Expected from sequence similarity: Human, Mouse, Dog, Pig, Cow
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Immunogen Sequence
Peptide with sequence KSDDDYEDYASNK-C, from the N Terminus (mature) of the protein sequence according to NP_944494.1; NP_000807.2; NP_944493.2.
Peptide Sequence + C
KSDDDYEDYASNK-C
Epitope
N Terminus (mature)
Note
This antibody is expected to recognize all three reported isoforms (NP_944494.1; NP_000807.2; NP_944493.2).
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-GABRG2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GABRG2 antibody
Peptide ELISA (EIA), Western Blot (WB)
Application Notes for anti-GABRG2 antibody
Pep-ELISA: antibody detection limit dilution 1:64000.
WB: Approx 55kDa band observed in Rat Brain lysates. Recommended concentration: 1-3ug/ml.
Immunohistochemistry (IHC) of anti-GABRG2 antibody
(2ug/ml) staining of Rat Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
NCBI/Uniprot data below describe general gene information for GABRG2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_944494.1
[Other Products]
NCBI Related Accession #
Manufactured in an ISO 9001:2008 Certified Laboratory.NP_000807.2; NP_944493.2; NP_899156.1[Other Products]
NCBI GenBank Nucleotide #
NM_198904.2
[Other Products]
UniProt Primary Accession #
P18507
[Other Products]
UniProt Secondary Accession #
Q6GRL6; Q6PCC3; Q9UDB3; Q9UN15; F5HB82[Other Products]
UniProt Related Accession #
P18507[Other Products]
NCBI Official Full Name
gamma-aminobutyric acid receptor subunit gamma-2 isoform 1
NCBI Official Synonym Full Names
gamma-aminobutyric acid type A receptor gamma2 subunit
NCBI Official Symbol
GABRG2 [Similar Products]
NCBI Official Synonym Symbols
CAE2; ECA2; GEFSP3
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NCBI Protein Information
gamma-aminobutyric acid receptor subunit gamma-2
UniProt Protein Name
Gamma-aminobutyric acid receptor subunit gamma-2
UniProt Synonym Protein Names
GABA(A) receptor subunit gamma-2
Protein Family
Gamma-aminobutyric acid receptor
UniProt Gene Name
GABRG2 [Similar Products]
NCBI Summary for GABRG2
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for GABRG2
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector . Functions as ligand-gated chloride channel.
Research Articles on GABRG2
1. Differential GABRG2 structure disturbances are correlated with disease severity.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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