Product Name
CETP (CETP (HGNC:1869)), Blocking Peptide
Product Synonym Names
Cholesteryl ester transfer protein; Lipid transfer protein I; CETP
Product Gene Name
CETP (HGNC:1869) blocking peptide
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Antibody/Peptide Pairs
CETP peptide (MBS9226892) is used for blocking the activity of CETP antibody (MBS9205860)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11597
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human CETP. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Secreted, extracellular space. Note: Secreted in plasma
Tissue Location
Expressed by the liver and secreted in plasma.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of CETP (HGNC:1869) blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
CETP (HGNC:1869) blocking peptide
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).
NCBI/Uniprot data below describe general gene information for CETP (HGNC:1869). It may not necessarily be applicable to this product.
NCBI Accession #
P11597.2
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UniProt Primary Accession #
P11597
[Other Products]
UniProt Secondary Accession #
Q13987; Q13988; Q53YZ1[Other Products]
UniProt Related Accession #
P11597[Other Products]
Molecular Weight
47,787 Da
NCBI Official Full Name
Cholesteryl ester transfer protein
NCBI Official Synonym Full Names
cholesteryl ester transfer protein
NCBI Official Symbol
CETP [Similar Products]
NCBI Official Synonym Symbols
BPIFF; HDLCQ10
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NCBI Protein Information
cholesteryl ester transfer protein
UniProt Protein Name
Cholesteryl ester transfer protein
UniProt Synonym Protein Names
Lipid transfer protein I
UniProt Gene Name
CETP [Similar Products]
UniProt Entry Name
CETP_HUMAN
NCBI Summary for CETP (HGNC:1869)
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
UniProt Comments for CETP (HGNC:1869)
CETP: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1). Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Vesicle; Secreted, signal peptide; Lipid-binding
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: extracellular region; extracellular space; vesicle
Molecular Function: cholesterol binding; cholesterol transporter activity; lipid binding; lipid transporter activity; phosphatidylcholine binding; phospholipid transporter activity; triglyceride binding
Biological Process: cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; lipid homeostasis; lipid transport; lipoprotein metabolic process; phosphatidylcholine metabolic process; phospholipid homeostasis; phospholipid transport; receptor-mediated endocytosis; reverse cholesterol transport; triacylglycerol metabolic process; triacylglycerol transport
Disease: Hyperalphalipoproteinemia 1
Research Articles on CETP (HGNC:1869)
1. Cholesteryl ester transfer protein facilitates the exchange of triglycerides from TG-rich VLDL-1 particles for cholesteryl esters from high-density lipoprotein (HDL) particles.
Precautions
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Disclaimer
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