Full Product Name
Goat anti-CETP Antibody
Product Synonym Names
CETP; cholesteryl ester transfer protein, plasma; HDLCQ10; lipid transfer protein; cholesteryl ester transfer protein; plasma antibody; HDLCQ10 antibody; lipid transfer protein antibody; CETP antibody
Product Gene Name
anti-CETP antibody
[Similar Products]
Antibody/Peptide Pairs
CETP peptide (MBS427241) is used for blocking the activity of CETP antibody (MBS422341)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
GNAHACSKGT SHEA
Species Reactivity
Expected from sequence similarity: Human
Purity/Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Form/Format
Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Concentration
100ug specific antibody in 200ul (lot specific)
Immunogen
Peptide with sequence GNAHACSKGTSHEA, from the N Terminus of the protein sequence according to NP_000069.2.
Preparation and Storage
Aliquot and store at -20 degree C. Minimize freezing and thawing.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-CETP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CETP antibody
Peptide ELISA (EIA)
Application Notes for anti-CETP antibody
Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Preliminary experiments gave bands at approx 48kDa and 28kDa in HepG2 lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 54.8kDa according to NP_000069.2. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).
NCBI/Uniprot data below describe general gene information for CETP. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000069.2
[Other Products]
NCBI GenBank Nucleotide #
NM_000078.2
[Other Products]
UniProt Secondary Accession #
Q13987; Q13988; Q53YZ1[Other Products]
UniProt Related Accession #
P11597[Other Products]
Molecular Weight
47,787 Da
NCBI Official Full Name
cholesteryl ester transfer protein isoform 1
NCBI Official Synonym Full Names
cholesteryl ester transfer protein
NCBI Official Symbol
CETP [Similar Products]
NCBI Official Synonym Symbols
BPIFF; HDLCQ10
[Similar Products]
NCBI Protein Information
cholesteryl ester transfer protein
UniProt Protein Name
Cholesteryl ester transfer protein
UniProt Synonym Protein Names
Lipid transfer protein I
Protein Family
Cholesteryl ester transfer protein
UniProt Gene Name
CETP [Similar Products]
UniProt Entry Name
CETP_HUMAN
NCBI Summary for CETP
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
UniProt Comments for CETP
CETP: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol. Defects in CETP are the cause of hyperalphalipoproteinemia type 1 (HALP1). Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL). Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid-binding; Secreted; Vesicle; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16q21
Cellular Component: extracellular region; extracellular space; vesicle
Molecular Function: cholesterol binding; cholesterol transporter activity; lipid binding; lipid transporter activity; phosphatidylcholine binding; phospholipid transporter activity; triglyceride binding
Biological Process: cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; lipid homeostasis; lipid transport; lipoprotein metabolic process; phosphatidylcholine metabolic process; phospholipid homeostasis; phospholipid transport; receptor-mediated endocytosis; reverse cholesterol transport; triacylglycerol metabolic process; triacylglycerol transport
Disease: Hyperalphalipoproteinemia 1
Research Articles on CETP
1. SNPs in SORT1, CETP and GCKR were individually associated with lipid level variations in Algerian population.
Precautions
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Disclaimer
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