BAFF, Monoclonal Antibody

Mouse Monoclonal [clone T7-241] (IgG1) to Human BAFF; TNFSF13B; B-cell-activating factor; BAFF; ApoL related ligand TALL-1; B-lymphocyte stimulator; CD257; BLYS; Delta4 BAFF; Delta BAFF; TALL-1; TALL1; ZTNF4; THANK; B lymphocyte stimulator; CD257 antigen; TNFSF20

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2a

Buffy-1

Rat

Recognizes membrane-bound human BAFF. Detects endogenous protein by FC.

Gel filtration

PBS, 0.02% sodium azide.

Short term: -20 degree C
Long term: -20 degree C.

Small volumes of anti-BAFF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Members in the TNF superfamily regulate immune responses and induceapoptosis. A novel member in the TNF family was recently identified byseveral groups and designated BAFF (for B cell Activating Factorbelonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1(for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (forTNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase).

TNF

Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)

IHC-P: 10 ug/ml

Anti-BAFF antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

17,578 Da

TNF superfamily member 13b

tumor necrosis factor ligand superfamily member 13B

Tumor necrosis factor ligand superfamily member 13B

BAFF; BLYS; TALL1; TNFSF20; ZTNF4; BLyS; TALL-1  [Similar Products]

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

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