Product Name
Neurogenin3 (NEUROG3), Polyclonal Antibody
Full Product Name
Neurogenin3, NT (NEUROG3, ATOH5, BHLHA7, NGN3, Neurogenin-3, Class A basic helix-loop-helix protein 7, Protein atonal homolog 5)
Product Synonym Names
Anti -Neurogenin3, NT (NEUROG3, ATOH5, BHLHA7, NGN3, Neurogenin-3, Class A basic helix-loop-helix protein 7, Protein atonal homolog 5)
Product Gene Name
anti-NEUROG3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 10; NC_000010.10 (71331791..71333210, complement). Location: 10q21.3
3D Structure
ModBase 3D Structure for Q9Y4Z2
Species Reactivity
Human, Mouse
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
Neurogenin3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47~76 amino acids from the N-terminal region of human Neurogenin3.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-NEUROG3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-NEUROG3 antibody
Neurogenin-3 belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm. Neurogenin-3 also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Defects in NEUROG3 are the cause of congenital malabsorptive diarrhea 4 (DIAR4). DIAR4 is an autosomal recessive disorder characterized by generalized malabsorption and a paucity of enteroendocrine cells.
Product Categories/Family for anti-NEUROG3 antibody
Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-NEUROG3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-NEUROG3 antibody
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Immunofluorescence: 1:10-50
NCBI/Uniprot data below describe general gene information for NEUROG3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_066279.2
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NCBI GenBank Nucleotide #
NM_020999.3
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UniProt Primary Accession #
Q9Y4Z2
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UniProt Secondary Accession #
Q5VVI0; Q6DJX6; Q9BY24[Other Products]
UniProt Related Accession #
Q9Y4Z2[Other Products]
Molecular Weight
23,077 Da[Similar Products]
NCBI Official Full Name
neurogenin-3
NCBI Official Synonym Full Names
neurogenin 3
NCBI Official Symbol
NEUROG3 [Similar Products]
NCBI Official Synonym Symbols
ngn3; Atoh5; NGN-3; Math4B; bHLHa7
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NCBI Protein Information
neurogenin-3; protein atonal homolog 5; class A basic helix-loop-helix protein 7
UniProt Protein Name
Neurogenin-3
UniProt Synonym Protein Names
Class A basic helix-loop-helix protein 7; bHLHa7; Protein atonal homolog 5
Protein Family
Neurogenin
UniProt Gene Name
NEUROG3 [Similar Products]
UniProt Synonym Gene Names
ATOH5; BHLHA7; NGN3; NGN-3; bHLHa7 [Similar Products]
UniProt Entry Name
NGN3_HUMAN
NCBI Summary for NEUROG3
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
UniProt Comments for NEUROG3
neurogenin 3: Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4). DIAR4 is a characterized by severe, life- threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.
Protein type: DNA-binding; Cell development/differentiation; Transcription factor
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component: cytoplasm; nucleus
Molecular Function: protein dimerization activity; chromatin DNA binding; double-stranded DNA binding; transcription coactivator activity
Biological Process: nervous system development; central nervous system development; transcription, DNA-dependent; regulation of dendrite morphogenesis; negative regulation of transcription from RNA polymerase II promoter; endocrine pancreas development; peripheral nervous system development; epithelial cell differentiation; spinal cord development; forebrain development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of neuron differentiation; hindbrain development
Disease: Diarrhea 4, Malabsorptive, Congenital
Research Articles on NEUROG3
1. Data indicate associations of SNPs in eight loci CXCR4, HHEX, FOXA2, NGN3, TCF7L2, FLJ39370 (C4orf32), LOC646279 (RPL21P7) and THADA with body mass index (BMI) and weight.
Precautions
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